Influence of the thyroid remnant in the elevation of the serum thyroglobulin after thyroidectomy in differentiated thyroid carcinoma. Importance of the diagnostic iodine total-body scanning.

European Journal of Nuclear Medicine and Molecular Imaging
Elisa Caballero-CalabuigJesús Félix-Fontestad

Abstract

Stimulated thyroglobulin (Tg) and (131)I total-body scan (TBS) have been the mainstays of differentiated thyroid carcinoma (DTC), but now diagnostic TBS has been eliminated from some follow-up protocols. Nevertheless, Tg can be negative in the presence of thyroid tissue, and moderately elevated Tg poses management problems. The purpose of this study was to check how many patients have Tg negative but visible thyroid tissue and if diagnostic TBS could be clinically useful. Retrospective review of 317 exams (stimulated Tg and TBS) of 128 patients with DTC. Patients with high-grade criteria and/or positive autoantibodies are excluded. Tg is considered positive if higher than the sensitivity level of the technique. TBS is positive if thyroid remnant, lymphatic node or metastases are detected. Results are classified in Tg and TBS concordant or discordant. Discordant (131)I TBS and Tg were found in 74/317 studies (23.3%), 48 (65%) being TBS positive and Tg negative. None of 128 patients had a first post-surgery negative scan, but 13 (10%) were Tg negative, even two patients with lymph node uptake. One year after radioiodine treatment, 26 out of 115 patients (initially Tg and TBS concordant positive) showed Tg negative and TBS still p...Continue Reading

References

Jul 1, 1994·The Journal of Clinical Endocrinology and Metabolism·M OzataL J DeGroot
Jan 29, 1998·The New England Journal of Medicine·M J Schlumberger
Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·L WartofskyI D Hay
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·E L Mazzaferri, R T Kloos
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·E L MazzaferriA Pinchera
Feb 7, 2004·European Journal of Endocrinology·Martin SchlumbergerWilmar M Wiersinga
Apr 26, 2005·Revista española de medicina nuclear·M D Abós Olivares, C Pesquera González
Nov 11, 2005·Journal of the National Comprehensive Cancer Network : JNCCN·David Ettinger, Bruce Johnson
May 27, 2006·European Journal of Endocrinology·Furio PaciniUNKNOWN European Thyroid Cancer Taskforce

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