Influence of the type of membrane and heparin on serum lipid parameters during a dialysis session: a pilot study

American Journal of Nephrology
Konstantinos P KatopodisKostas C Siamopoulos

Abstract

The type of heparin and membrane used might influence the lipids in patients on hemodialysis (HD). However, there are limited and debatable data concerning the lipid changes during an HD session. The aim of our study was to examine the changes in serum lipid parameters during the HD session in relation to the heparin and dialysis membrane used. Ten patients on HD 3 times/week participated in the study. The study was performed in three phases (A, B, C), each of 1 week's duration. The types of membranes used were Hemophan (phase A), ethylene vinyl alcohol (phase B) and polyacrylonitrile (phase C), respectively, in a random order. During the midweek session of each phase we used classic heparin, while during the session at the end of the week low molecular weight heparin was administered. Serum total cholesterol, triglycerides, HDL cholesterol, Lp(a), albumin and total proteins were measured before and 5 min after the HD and hourly during the HD session. In all phases, we found a progressive increase in all lipid parameters during the HD session, except Lp(a). This increase, however, was possibly due to hemoconcentration. This pilot study showed that (1) the type of heparin and membrane used does not seem to affect the serum lipid...Continue Reading

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Citations

Feb 7, 2007·International Urology and Nephrology·H Abo-ZenahM Sobh
Sep 15, 2006·Seminars in Dialysis·Jia LiuMitchell H Rosner
Aug 17, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tetsuo Shoji, Yoshiki Nishizawa
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Konstantinos P KatopodisKostas C Siamopoulos

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