PMID: 9177490Jan 1, 1997Paper

Influence of the Ward colon tumor on the host response to endotoxin

Journal of Cancer Research and Clinical Oncology
V B Grossie, D Mailman

Abstract

Cachexia and a decreased immune function are negative prognostic factors for cancer patients. While the decreased immunity results in a greater susceptibility to bacterial infection, the response of the host to the resulting infection is not clear. The experiments reported here were designed to evaluate the toxicity of endotoxin to rats with a transplantable Ward colon tumor (WCT) and to evaluate the mechanism of the observed increase in lethal toxicity. The lethal toxicity of endotoxin (lipopolysaccharide, LPS) at 5 mg/kg, i.p. was evaluated in the first of two experiments. Rats received LPS and were observed for morbidity and weight loss for a period of 11 days. A second experiment was done to evaluate the effect of LPS on the plasma nitrate/nitrite concentrations and plasma indicators of host tissue dysfunction. LPS was administered as previously described but blood and tissues were collected 5 h after LPS administration. LPS resulted in the death of 1 of 12 nontumor-bearing (NTB) rats and a transient weight loss in the survivors. This same dose of LPS, however, resulted in death for 10 of 12 WCT rats with tumor burdens less than 4% of body weight. The response of WCT rats 5 h after LPS was then compared with that of age-mat...Continue Reading

References

Feb 1, 1990·Immunological Investigations·A D YurochkoK D Elgert
Feb 1, 1974·Cancer·J InagakiG P Bodey
Apr 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J KlasterskyA Verhest
May 1, 1980·The American Journal of Medicine·D W NixonD Rudman
Jan 1, 1983·Immunological Communications·C J Burger, K D Elgert
Dec 15, 1993·Biochemical and Biophysical Research Communications·C A RobertsonS K Grant
May 25, 1995·Biochemical and Biophysical Research Communications·W W WangL J Ignarro
Aug 1, 1995·The Journal of Surgical Research·T E GardnerJ M Daly
Jul 1, 1995·International Journal of Immunopharmacology·T R DownsJ F French

❮ Previous
Next ❯

Citations

Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Robert D WinfieldLyle L Moldawer
Jun 9, 2005·American Journal of Physiology. Endocrinology and Metabolism·Michelle L MackenzieVickie E Baracos
Jun 1, 2001·Nitric Oxide : Biology and Chemistry·D MailmanF Murad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.