Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes

International Journal of Antimicrobial Agents
V TullioN A Carlone

Abstract

Current antibiotic therapy encourages the use of antibiotics that may potentiate the host's immune defences. We therefore investigated the effect of thiamphenicol (TAP), the active principle of thiamphenicol glycinate acetylcysteinate (TGA), on human granulocyte functions, mainly phagocytosis and intracellular killing of Streptococcus pyogenes. Our findings support the use of thiamphenicol in the treatment of respiratory tract infections caused by S. pyogenes as it acts directly against the pathogen as well as in cooperation with PMNs by eliciting their intracellular killing.

Citations

Jun 30, 2010·Antimicrobial Agents and Chemotherapy·Vivian TullioNicola A Carlone
Aug 8, 2008·Basic & Clinical Pharmacology & Toxicology·Paulina L PáezInés Albesa
Sep 10, 2014·Current Opinion in Pharmacology·Giuliana BancheAnna Maria Cuffini
Oct 30, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Patrizia ChetoniRoberta Cavalli

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