PMID: 6972998Jun 1, 1981Paper

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice

The Journal of Experimental Medicine
Argyrios N TheofilopoulosF J Dixon

Abstract

In young adulthood, MRL/Mp-lpr/lpr mice develop severe systemic lupus erythematosus (SLE)-like syndrome associated with massive T cell proliferation. The congenic MRL/Mp- mice lack the lpr gene and develop chronic SLE late in life. We have exchanged thymic transplants between these substrains so as to determine the role of the thymus in the development of early, severe SLE and of lymphoproliferation. The median survival times of unmanipulated lpr/lpr and mice were 160 and 510 d, respectively. The lpr/lpr and mice thymectomized when newborn and transplanted at 1 mo with the opposite type of thymus retained the diseases phenotype of their unmanipulated counterparts with 50% mortality at 186 and 498 d, respectively. In contrast, lpr/lpr mice thymectomized when newborn but not transplanted with thymus did not develop lymphoid hyperplasia and glomerulonephritis, and 100% of them were alive at 390 d. Serologically, the thymectomized but untransplanted lpr/lpr mice had significantly reduced levels of autoantibodies, whereas thymectomized and transplanted mice of either substrain were similar to unmanipulated controls. The results indicate that: (a) a thymus is essential for expression of lymphoproliferation and early SLE-like disease ...Continue Reading

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Citations

Dec 1, 1986·Agents and Actions·A N Theofilopoulos
Jan 1, 1986·Springer Seminars in Immunopathology·A N TheofilopoulosF J Dixon
Jun 1, 1989·Research in Immunology·A L Spetz-Hagberg, E L Larsson-Sciard
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C KuboR A Good
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G Fernandes, R A Good
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W F DavidsonH C Morse
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P A SingerA N Theofilopoulos
Mar 1, 1983·The Journal of Experimental Medicine·L HangF J Dixon
Jun 1, 1983·The Journal of Experimental Medicine·G J Prud'hommeA N Theofilopoulos
Jul 1, 1985·The Journal of Experimental Medicine·A N TheofilopoulosF J Dixon
Mar 1, 1986·The Journal of Experimental Medicine·D J NoonanA N Theofilopoulos
Mar 1, 1988·The Journal of Experimental Medicine·T KatagiriR A Eisenberg
May 1, 1988·The Journal of Experimental Medicine·T J SantoroB L Kotzin
Dec 1, 1988·The Journal of Experimental Medicine·B L KotzinL R Herron
Jan 1, 1991·The Journal of Experimental Medicine·K MatsumotoK Nomoto
Dec 1, 1991·The Journal of Experimental Medicine·C KimA Ochi
Dec 1, 1991·Scandinavian Journal of Immunology·J Reimann
Jan 1, 1993·Scandinavian Journal of Immunology·J A GonzaloG Kroemer
Apr 21, 1995·Annals of the New York Academy of Sciences·H Cantor
Jan 1, 1994·International Reviews of Immunology·A Shirai, D M Klinman
Jan 1, 1994·International Reviews of Immunology·A BhandoolaM I Greene
Jan 1, 1994·International Reviews of Immunology·M Kimura, A Matsuzawa
Jan 1, 1994·International Reviews of Immunology·J D MountzC K Edwards
Jan 1, 1992·Autoimmunity·T W CroghanP L Cohen
Apr 16, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Virginie TardifBrian R Lawson
Jul 1, 1985·Parasite Immunology·S P NickellM H Boyer
Apr 1, 1984·Immunological Reviews·G J Prud'hommeA N Theofilopoulos
Nov 1, 1989·Clinical Immunology and Immunopathology·B L KotzinE Palmer
Mar 1, 1984·Immunology Today·Y J RosenbergT J Santoro
Apr 1, 1990·Journal of Autoimmunity·P A Singer, A N Theofilopoulos

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