Influence of thyroid function on glomerular filtration rate and other estimates of kidney function in two pediatric patients

CEN Case Reports
Osamu UemuraKazuki Tanaka

Abstract

To determine the optimal method of evaluating kidney function in patients with thyroid dysfunction, this study compared the estimated glomerular filtration rate derived from serum creatinine, cystatin C, or β2-microglobulin with inulin or creatinine clearance in two pediatric patients, one with hypothyroidism and the other with hyperthyroidism. It was observed that the kidney function decreased in a hypothyroid child and enhanced in a hyperthyroid child, with their kidney function becoming normalized by treatment with drugs, which normalized their thyroid function. Kidney function cannot be accurately evaluated using cystatin C-based or β2-microglobulin-based estimated glomerular filtration rate in patients with thyroid dysfunction, as these tests overestimated glomerular filtration rate in a patient with hypothyroidism and underestimated glomerular filtration rate in a patient with hyperthyroidism, perhaps through a metabolic rate-mediated mechanism. In both our patients, 24-h urinary creatinine secretion was identical before and after treatment, suggesting that creatinine production is not altered in patients with thyroid dysfunction. Therefore, kidney function in patients with thyroid dysfunction should be evaluated using cr...Continue Reading

References

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Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Genoveva del-Río CamachoJulio Romero González
Apr 5, 2003·Kidney International·Manuel FrickerChristoph Schmid
Dec 20, 2003·American Journal of Nephrology·Georgios KaranikasKurt Kletter
May 22, 2008·The Journal of Pediatrics·Aziz ElgadiUlla B Berg
Aug 19, 2011·Kidney & Blood Pressure Research·Martin KimmelMark Dominik Alscher
Nov 21, 2013·Clinical and Experimental Nephrology·Osamu UemuraMasataka Honda
Aug 2, 2014·Clinical and Experimental Nephrology·Yohei IkezumiMasataka Honda
Aug 26, 2014·World Journal of Gastroenterology : WJG·Bülent YılmazSerap Arslan

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Citations

Dec 22, 2020·International Journal of Nephrology·Fateme Shamekhi Amiri

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