Influence of thyroid status on water metabolism and survival of normal and dehydrated desert rodents Meriones libycus

General and Comparative Endocrinology
R B Chaouacha-ChekirF Lachiver

Abstract

The relationship between thyroid status and resistance to water deprivation in a desert rodent, Meriones libycus, has been studied in normal, radiothyroidectomized (Tx), and thyroidectomized T4-supplemented (1.5 microg T4/day) (Tx + T4) animals. In animals given free access to water, 1 month after thyroidectomy water influx and efflux decreased 3-fold. This decrease was partially corrected after 5 days of T4 administration. Thyroidectomy did not modify urinary osmolality nor affect survival. In dehydrated animals, the body weight decreased (about 15%) over 2 weeks in all groups and then stabilized. Water flux decreased sharply in normal or Tx + T4 animals during the 1st week and then stabilized. A further decrease of water flux occurred in hypothyroid animals, which continued over 4 weeks, when fluxes were half those of normal or Tx + T4 animals. The urinary osmolality increased equally sharply in the three groups, at least during the first 5 days of dehydration when sampling was possible. Whereas dehydrated normal and Tx + T4 animals survived at least 7 weeks, 70% of Tx animals had died after 4 weeks and none survived more than 7 weeks. The daily metabolic energy intake was estimated from water flux and metabolic water of the ...Continue Reading

Citations

Oct 11, 2007·European Journal of Endocrinology·Daniel Kelberman, Mehul Tulsidas Dattani
May 28, 2002·Journal of Endocrinological Investigation·P J DavisM Wehling

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