Influence of timing and oral anticoagulant/antiplatelet therapy on outcomes of patients affected by hip fractures

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
F DettoniR Rossi

Abstract

Patients undergoing surgical procedures are usually asked to discontinue any anticoagulant/antiplatelet therapy and delay surgery for at least 5 days to reduce the risk of major bleeding and spinal hematoma. The purpose of this study was to determine if this strategy is suitable for patients on anticoagulant/antiplatelet therapy affected by a hip fracture, evaluating the effect of anticoagulant/antiplatelet therapy and surgical timing on mortality and complication rates for patients affected by a hip fracture. We performed an observational study on patients referring to our hospital for a hip fracture. We evaluated patients on warfarin, ticlopidine, and aspirin therapy matched to patients not on anticoagulant or antiplatelet therapy, out of 875 consecutive patients treated for a hip fracture in a 5-year period. Blood loss, blood transfusions, length of hospitalization, walking ability, complications, and mortality at 1 year of follow-up were recorded. Kruskal-Wallis, Mann-Whitney U, and logistic regression statistical tests were performed. Patients on warfarin therapy operated more than 5 days after admission showed significantly higher complication and mortality rates compared to all other patients. Two critical factors were i...Continue Reading

References

Nov 1, 1989·The British Journal of Surgery·S TravisK Harrison
Dec 1, 1994·Anesthesia and Analgesia·E P VandermeulenJ Vermylen
Apr 1, 1997·Journal of Orthopaedic Trauma·G B AharonoffJ D Zuckerman
Jun 3, 1998·British Journal of Haematology
Dec 9, 1998·Regional Anesthesia and Pain Medicine·F K Enneking, H Benzon
Dec 22, 1999·Hospital Medicine·R F ArmstrongH Breivik
May 9, 2001·Thrombosis Research·T T Horlocker
Sep 22, 2001·The Medical Clinics of North America·J Spandorfer
Dec 24, 2002·Current Opinion in Cardiology·Michael D Ezekowitz, Pavlo I Netrebko
Feb 15, 2003·Thrombosis Research·Per Morten Sandset, Ulrich Abildgaard
Oct 8, 2003·Best Practice & Research. Clinical Anaesthesiology·Patrick Narchi
Dec 3, 2003·Cleveland Clinic Journal of Medicine·Amir K JafferNkem Chukwumerije
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Gretchen M OroszAlbert L Siu
Oct 29, 2004·Journal of Clinical Pathology·J P Hanley
Mar 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Christopher G MoranAndrew M Taylor
Apr 30, 2005·Transfusion Medicine·A SalamatH G Watson
Jul 29, 2005·The Journal of Bone and Joint Surgery. British Volume·A W SiegmethM J Parker
Oct 6, 2005·Clinical Orthopaedics and Related Research·Mary F DillonJohn Mac Elwaine
Oct 11, 2005·Injury·Mamun Al-Rashid, Martyn J Parker
Oct 21, 2005·International Journal of Clinical Practice·R Bansal, D K Watson
Nov 3, 2005·Annals of the Royal College of Surgeons of England·D G MorrittM H Stone
Jan 18, 2006·British Journal of Haematology·T P BaglinUNKNOWN British Committee for Standards in Haematology
Mar 24, 2006·BMJ : British Medical Journal·Alex Bottle, Paul Aylin
Aug 1, 2006·The Journal of Bone and Joint Surgery. British Volume·N B Foss, H Kehlet
Jan 11, 2007·Journal of Orthopaedic Trauma·Pritam TharmarajahKeith Willett
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·N Von MeibomB Davis
Feb 21, 2007·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Victor NovackAvi Porath
Sep 7, 2007·ANZ Journal of Surgery·Hamish C RaeTeodora Todorova

❮ Previous
Next ❯

Citations

Apr 18, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Harun Yasin TüzünÖmer Erşen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal - Canadian Dental Association = Journal De L'Association Dentaire Canadienne
Adeela NematullahSusan E Sutherland
Revista española de anestesiología y reanimación
F ReguantJ Bosch
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
D G Sherman
© 2021 Meta ULC. All rights reserved