Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Mediators of Inflammation
Marco A Rocha LouresJeane Eliete Laguila Visentainer

Abstract

Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms of TNF and IL17 genes are associated with SpA, ankylosing spondylitis (AS), and psoriatic arthritis (PsA) in a mixed Brazilian population. Genotyping of TNF-308 (rs1800629), TNF-238 (rs361525), IL17A (rs2275913), IL17F (rs763780), and HLA-B27 polymorphisms was performed in 243 patients with SpA and 210 controls from Southern Brazil using SSOP-Luminex (One Lambda) and PCR-SSP assays. Significant associations were confirmed between the HLA-B27 marker and SpA, AS, and PsA diseases. While TNF-308 (rs1800629) AA/GA, IL17A (rs2275913) AA/GA, and IL17F (rs763780) CC/TC genotype frequencies were associated, in the dominance inheritance model, with SpA and AS, regardless of gender, the presence of HLA-B27, TNF-238 (rs361525) GA/AA, IL17A (rs2275913) AA/GA, and IL17F (rs763780) genotypes was associated with PsA. In this Brazilian population, TNF and IL17 gene polymorphisms responsible for the expression of important inflammatory cytokines were associated with...Continue Reading

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Citations

Nov 28, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan Manuel Cubillos-AnguloBruno B Andrade
Nov 5, 2020·Clinics·Fernanda Formaggi Lara-ArmiAna Maria Sell
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Oct 28, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Fridha Viridiana Villalpando-VargasOmar Graciano-Machuca

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Methods Mentioned

BETA
Genotyping

Software Mentioned

SNPStats
OpenEpi
Quanto

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