Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin

Skin Pharmacology and Physiology
Juergen LademannOlivier Doucet

Abstract

The formation of free radicals in human skin by solar ultraviolet radiation is considered to be the main reason for extrinsic skin aging. The antioxidants in human tissue represent an efficient protection system against the destructive action of these reactive free radicals. In this study, the parameters of the skin, epidermal thickness, stratum corneum moisture, elasticity and wrinkle volume, were determined before and after the treatment with antioxidant- or placebo-containing tablets and creams. The study included 5 groups of 15 volunteers each, who were treated for 2 months with antioxidant-containing or placebo tablets, creams or a combination of antioxidant-containing tablets and cream. The skin parameters were measured at time point 0 and at week 8 utilizing ultrasound for the determination of epidermal thickness, a corneometer for stratum corneum moisture measurements, skin profilometry for quantifying the wrinkle volume and a cutometer for determining the elasticity. The verum cream had a positive influence on epidermal thickness, elasticity and skin moisture, but the verum tablets improved the epidermal thickness only. The combined application of verum tablets and creams led to a significant improvement of all investi...Continue Reading

Citations

Jan 7, 2020·Annual Review of Food Science and Technology·Brittany WoodbyGiuseppe Valacchi
Jun 1, 2020·Journal of Biophotonics·Armin MorovatiValery V Tuchin
Dec 1, 2017·Anais Brasileiros De Dermatologia·Flavia Alvim Sant'anna Addor
Feb 14, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Sora JungJürgen Lademann
Jul 3, 2021·Antioxidants·Luciana de Souza GuedesAndré Rolim Baby

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