Influence of topoisomerase II inhibitors and ionizing radiation on growth arrest and cell death pathways in the breast tumor cell

Cell Biochemistry and Biophysics
D A GewirtzK J Magnet

Abstract

Promotion of apoptosis (which is frequently dependent on functional p53) is thought to be critical for the effectiveness of chemotherapy or radiotherapy. Studies in this as well as other laboratories have demonstrated that breast tumor cells are relatively refractory to apoptosis in response to modalities that induce DNA damage. This report describes our efforts to understand the basis for the absence of an apoptotic response to adriamycin and ionizing radiation in the breast tumor cell based on alterations in cell-cycle and apoptotic regulatory proteins. We also report on the permissive effects of Vitamin D3 and the Vitamin D3 analog EB 1089 in the promotion of apoptosis in p53-wild-type cells. Our studies suggest that regulation of apoptosis in the breast tumor cell may require modulation of signaling events other than or in addition to the p53-dependent DNA damage response.

Citations

Oct 10, 2006·Breast Cancer Research and Treatment·Alina Carmen PorojnicuJohan Moan
Sep 26, 2013·European Journal of Cell Biology·Gabriela Nestal de MoraesRaquel C Maia
May 20, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Alexander HoMarios Loukas
May 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Cornelius Kwang-Lee Chieng, Yee-How Say

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