Influence of trace elements in human tissue in low-energy photon brachytherapy dosimetry

Physics in Medicine and Biology
Shane A WhiteBrigitte Reniers

Abstract

The aim of this paper is to determine the dosimetric impact of trace elements in human tissues for low-energy photon sources used in brachytherapy. Monte Carlo dose calculations were used to investigate the dosimetric effect of trace elements present in normal or cancerous human tissues. The effect of individual traces (atomic number Z = 11-30) was studied in soft tissue irradiated by low-energy brachytherapy sources. Three other tissue types (prostate, adipose and mammary gland) were also simulated with varying trace concentrations to quantify the contribution of each trace to the dose distribution. The dose differences between cancerous and healthy prostate tissues were calculated in single- and multi-source geometries. The presence of traces in a tissue produces a difference in the dose distribution that is dependent on Z and the concentration of the trace. Low-Z traces (Na) have a negligible effect (<0.3%) in all tissues, while higher Z (K) had a larger effect (>3%). There is a potentially significant difference in the dose distribution between cancerous and healthy prostate tissues (4%) and even larger if compared to the trace-free composition (15%) in both single- and multi-sourced geometries. Trace elements have a non-ne...Continue Reading

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Citations

Jul 5, 2013·Medical Physics·Kari TanderupJoanna E Cygler
Apr 8, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Vladimir Zaichick, Sofia Zaichick
Feb 10, 2017·Physics in Medicine and Biology·Bianca BerndtKatia Parodi
Aug 26, 2014·Physics in Medicine and Biology·S MashoufJ P Pignol
Jan 4, 2021·Radiation and Environmental Biophysics·Vladimir Zaichick, Sinclair Wynchank

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