PMID: 2110294May 1, 1990Paper

Influence of treatment to sacrifice time and the presence of BrdUrd on chemically-induced aberration rates in mouse marrow cells

Mutation Research
A F McFee, R R Tice

Abstract

4 chemicals, with various modes of clastogenic action were used to evaluate induced chromosomal aberrations in mouse bone marrow at different times after intraperitoneal injection. Aberration frequencies induced by mitomycin C, cyclophosphamide and dimethylbenz[a]anthracene increased with increasing time between treatment and sampling until those time points (approximately 18 h) when significant proportions of second-division metaphases were among the cells being scored; this increase was not obvious following treatment with 4-nitroquinoline 1-oxide. When BrdUrd tablets were implanted prior to treatment and scoring was restricted to first-division metaphases, aberration rates continued to increase for as long as 24 h post-treatment. The presence of BrdUrd did not affect significantly the rate of aberration induction by the chemicals. Our data indicate that the sensitivity of the in vivo mouse marrow assay for clastogenic chemicals can be greatly increased by utilizing BrdUrd to insure the scoring of only first-division metaphases at post-treatment times of approx. 18 h.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E L SchneiderR R Tice
Apr 30, 1979·Radiation and Environmental Biophysics·A A EdwardsR J Purrott
Jan 1, 1986·Environmental Mutagenesis·R W TennantJ W Spalding
Oct 1, 1982·Mutation Research·U KlieschI D Adler
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L MiglioreN Loprieno

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Citations

Jan 1, 1994·Journal of Neuro-oncology·A FreeseM J O'Connor
Nov 13, 2008·Cytotechnology·Serkan YılmazHüseyin Aksoy
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J MukhopadhyayA Mukherjee
Apr 1, 1993·Environmental Health Perspectives·R W Tennant, E Zeiger
May 19, 2006·International Journal of Environmental Research and Public Health·Babu P PatlollaPaul B Tchounwou
Jan 14, 2016·Drug and Chemical Toxicology·Ilika Ghosh, Anita Mukherjee
Jan 18, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·David KirklandRaffaella Corvi
Mar 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D YüzbaşıoğluF Demirtaş Korkmaz
Dec 7, 2007·Mutation Research·Deniz YüzbaşioğluMustafa Celik

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