PMID: 11337009May 5, 2001Paper

Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats

Mechanisms of Ageing and Development
M SabbatiniF Amenta

Abstract

Hypertension is the main cause of stroke that represents the second most common cause of death in the industrialized world and a leading cause of inability of the elderly. Lowering blood pressure reduces cerebrovascular morbidity and mortality, but it is still controversial if blood pressure should be lowered in elderly individuals with concomitant cerebrovascular disease. The present study has analyzed comparatively the effect of treatment with the dihydropyridine-type Ca(2+) channel blockers lercanidipine, manidipine and nimodipine and with the non dihydropyridine-type vasodilator hydralazine on hypertension-dependent cerebrovascular changes in spontaneously hypertensive rats (SHR). Analysis included medium and small sized pial arteries and intracerebral arteries of frontal cortex, hippocampus, striatum, and cerebellum. In control SHR, systolic pressure (SBP) values were significantly higher in comparison with WKY rats. Pharmacological treatment significantly decreased SBP values, with nimodipine reducing only moderately SBP. In control SHR, thickening of arterial wall accompanied by luminal narrowing with consequent increase of the wall-to-lumen ratio occurred both in pial and intracerebral arteries. Dihydropyridine-type Ca(...Continue Reading

References

Dec 1, 1992·Journal of Cardiovascular Pharmacology·A TojoT Sugimoto
Jun 1, 1992·Trends in Pharmacological Sciences·W A Catterall, J Striessnig
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S MacMahon
Mar 1, 1990·Stroke; a Journal of Cerebral Circulation·M C Wong, E C Haley
Feb 2, 1989·The American Journal of Cardiology·D I Barry
Jun 1, 1989·Hypertension·G L Baumbach, D D Heistad
Dec 1, 1988·Journal of Neurosurgery·H G HöllerhageG F Walter
Jan 1, 1986·General Pharmacology·I TakayanagiK Yamada
Apr 1, 1985·Canadian Journal of Physiology and Pharmacology·C R Triggle, I Laher
Apr 1, 1985·Canadian Journal of Physiology and Pharmacology·R M Lee, J S Smeda
Feb 1, 1986·Neurosurgery·J ZabramskiC Bonstelle
Apr 1, 1985·Japanese Circulation Journal·K WatanabeY Yamori
Jan 1, 1983·British Medical Journal·O BertelU C Dubach
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·B B Weksler, M Lewin
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·M Kotila
May 1, 1981·Stroke; a Journal of Cerebral Circulation·Y NakatomiT Omae
May 1, 1980·Stroke; a Journal of Cerebral Circulation·C Nordborg, B B Johansson

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Citations

May 16, 2015·Neuroscience and Biobehavioral Reviews·Xiao OuBenjamin I Goldstein
Oct 27, 2004·Expert Review of Cardiovascular Therapy·Valérie TikhonoffAchille C Pessina
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Maurizio SabbatiniFrancesco Amenta

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