Influence of tumor-associated macrophages and HLA class I expression according to HPV status in head and neck cancer patients receiving chemo/bioradiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Dan OuYungan Tao

Abstract

To investigate the prognostic value of tumor-associated macrophages (TAM) and HLA class I expression according to HPV status in patients with head and neck squamous cell carcinoma treated with definitive radiotherapy combining cisplatin (CRT) or cetuximab (BRT). Ninety-five patients were enrolled. The density of CD68+ cells and CD68+ CD163+ cells (further referred as M2) in the intraepithelial and the stromal compartments, respectively, as well as HLA class I expression in tumor cells, were evaluated semi-quantitatively. Correlations between biomarker expression and treatment outcomes were analyzed. Multivariate analysis showed that the intraepithelial macrophage density (IEMD) was prognostic for favorable progression-free survival (PFS) and there was a non-significant trend for improved overall survival (OS). HLA class I down-regulation was not an independent prognostic factor. Subgroup analysis showed that in p16+ population, patients with high IEMD had improved 5-year PFS vs. patients with low IEMD (81.2% vs. 25.0%, p < 0.001), while in p16- population, no difference was observed. Similarly, when stratified by primary tumor site, IEMD showed prognostic value in oropharyngeal cancer patients (OPC) but not non-OPC patients. Fi...Continue Reading

References

Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-Pierre PignonUNKNOWN MACH-NC Collaborative Group
Feb 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Esther M de KruijfPeter J K Kuppen
Apr 20, 2010·Current Opinion in Oncology·Yungan TaoJean Bourhis
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicolas F SchlechtMichael B Prystowsky
Feb 3, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Nobuyuki FujiiHisao Ito
Aug 14, 2012·Frontiers in Oncology·Chi-Shiun ChiangJi-Hong Hong
Oct 6, 2012·Critical Reviews in Oncology/hematology·Antonin LevyEric Deutsch
Feb 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raghvendra M SrivastavaRobert L Ferris
Jul 31, 2013·Immunobiology·Maria Rosaria GaldieroSébastien Jaillon
Mar 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Antonin LevyYungan Tao
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Edith M G van EschSjoerd H van der Burg
Nov 5, 2014·Frontiers in Immunology·Paola Italiani, Diana Boraschi
Apr 11, 2015·Cancer Cell·Brian Ruffell, Lisa M Coussens
Dec 19, 2015·Cancer Cell·Lorenzo GalluzziGuido Kroemer
Jul 23, 2016·Pathology International·Motohiro Takeya, Yoshihiro Komohara
Sep 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura Q M ChowTanguy Y Seiwert
Oct 28, 2016·International Journal of Cancer. Journal International Du Cancer·Francisco PereaFrancisco Ruiz-Cabello
Jan 25, 2017·Nature Reviews. Clinical Oncology·Alberto MantovaniPaola Allavena
Jan 28, 2017·CA: a Cancer Journal for Clinicians·William M LydiattJatin P Shah

❮ Previous
Next ❯

Citations

Jul 1, 2020·Current Oncology Reports·Niels E WondergemRieneke van de Ven
Aug 11, 2020·Journal for Immunotherapy of Cancer·Saskia J SantegoetsSjoerd H van der Burg
Jan 12, 2021·Frontiers in Oncology·Marij J P WeltersSjoerd H van der Burg
Apr 26, 2021·Experimental Dermatology·Duygu Gülserenİlhan Tezcan
Aug 16, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C ChargariE Deutsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.