Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients With Irritable Bowel Syndrome

Psychosomatic Medicine
Michiko KanoShin Fukudo

Abstract

We investigated whether certainty and uncertainty of impending aversive visceral sensation differently modulate regional brain activity, both during anticipation and visceral sensation in irritable bowel syndrome (IBS) patients compared with healthy controls. Twenty-six IBS patients (14 women) and 29 healthy controls (15 women) were enrolled in a functional magnetic resonance imaging study. Participants received rectal distention at an individually titrated severe discomfort level that was preceded by visual cues to induce certain (100% chance of distention), uncertain (50% chance), and safe (0% chance) anticipation. Subjective ratings of anticipatory fear before and discomfort during distention were similar between IBS and control participants under cued certainty and uncertainty (p > .05). Uncertain anticipation compared with certain anticipation induced greater activation of anterior midcingulate cortex, thalamus, and visual processing areas in IBS patients compared with controls. Rectal distention after the uncertain, but not certain, cue induced higher activity in the posterior- and midcingulate cortices and the precuneus in IBS compared with controls. Controls exhibited bilateral insula activation during the nondistention...Continue Reading

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Citations

Sep 27, 2018·Annals of the New York Academy of Sciences·Nathalie WeltensMichiko Kano
Mar 7, 2020·The Tohoku Journal of Experimental Medicine·Michiko KanoShin Fukudo
Oct 5, 2017·Psychosomatic Medicine·Joel E Dimsdale
Jun 20, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Harman RahalLin Chang
Apr 9, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Bruce D NaliboffKirsten Tillisch
Feb 5, 2021·Journal of Gastroenterology·Shin FukudoKazuhiko Koike

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