Influence of unit distance and conduction velocity on the spectra of extracellular action potentials recorded with intrafascicular electrodes

Medical Engineering & Physics
Shaoyu Qiao, K Yoshida

Abstract

The use of highly selective penetrating electrodes yields multi-unit extracellular action potential (AP) recordings of the nerve fibers in the vicinity of the electrode. Accessing the information carried within the neural data stream further requires discrimination and separation of the multi-unit recording into their constituent multiple single unit spike trains. Shape differences in the single fiber action potentials (SFAPs) are typically used as the criteria for unit separation. The present paper explores the origins of the shape differences through analysis of the SFAP in the frequency domain. We present the derivation and computational model predictions of a method to quantitatively analyse changes in the spectral components of SFAPs with an axially located intrafascicular electrode with non-radially symmetrical sensitivity function. A spatial tissue filter relationship was derived using reciprocity equations in the spatial frequency domain and transformed to time frequency. A three dimensional bioelectrical volume conductor finite element model of a recording electrode residing in a nerve fascicle was developed to explore the potential distribution in the nerve fascicle and further derive the electrode-fiber coupling func...Continue Reading

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Citations

Mar 27, 2016·Medical & Biological Engineering & Computing·Olivier RosselGuy Cathébras
Oct 16, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Shaoyu QiaoKen Yoshida
Jan 1, 2017·Biomedical Physics & Engineering Express·L ChenB Feng
Oct 25, 2017·Neurosurgical Review·Ronald SahyouniHarrison W Lin
Nov 4, 2020·Journal of Neural Engineering·Giulia BaldazziDanilo Pani

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