Influence of V1 and V3 isomyosins on the mechanical behaviour of rat papillary muscle as studied by pseudo-random binary noise modulated length perturbations

Journal of Muscle Research and Cell Motility
G H RossmanithL J Kwan

Abstract

Experiments were done on four-week-old rats, containing biochemically verified V1 only, and thyroidectomized adult rats, treated with propylthiouracil, verified to contain V3 only. Contracture tension was induced in isolated papillary muscles either by high potassium solution or 0.5 mmol l-1 Ba2+. Small amplitude length perturbations with peak-to-peak value not exceeding 0.15% L0 were applied to the activated muscle. Both the applied length perturbations and the corresponding resulting force changes were analysed by computer for dynamic stiffness and phase values. In order to reduce data acquisition time, pseudo-random binary noise length changes, rather than the conventional sinusoidal length changes, were used. The plot of the dynamic stiffness against frequency displays a minimum, akin to a resonance phenomenon. The frequency, fmin, at which this resonance occurs, reflects crossbridge kinetics. It was found that the fmin values for the two types of papillary muscles differed by a factor of two. Experiments were also done on chemically skinned muscles containing V1 or V3 isomyosin activated by different concentrations of either barium or calcium ions. It was found that fmin values of skinned fibres were higher than those obta...Continue Reading

References

Nov 1, 1979·Nature·A M LompreB Swynghedauw
Dec 1, 1978·The Journal of General Physiology·G B McClellan, S Winegrad
Mar 1, 1978·Circulation Research·G J SteigerS T Tan
Mar 1, 1978·Circulation Research·Y SaekiH Suga
Feb 1, 1977·The Journal of General Physiology·N M De ClerckD L Brutsaert
Aug 1, 1986·Journal of Muscle Research and Cell Motility·G H Rossmanith
Jul 1, 1967·The Journal of General Physiology·M Bárány
Mar 1, 1971·The Journal of Physiology·M Bárány, R I Close
Mar 1, 1973·Circulation Research·D L BrutsaertM A Goethals
Oct 1, 1967·The Journal of Clinical Investigation·R A BuccinoE Braunwald
Jul 1, 1967·Journal of Biochemistry·S EbashiA Kodama
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A M SinhaM Rabinowitz
Sep 8, 1980·FEBS Letters·B PopeA Weeds
Dec 1, 1983·Journal of Muscle Research and Cell Motility·A S Cheung, B F Gray
Mar 1, 1982·Journal of Muscle Research and Cell Motility·D S LoiselleJ F Hoh
Sep 1, 1980·Journal of Muscle Research and Cell Motility·R Cuminetti, G Rossmanith
Jan 1, 1980·European Heart Journal·D G Allen, S Kurihara
Dec 1, 1981·Journal of Molecular and Cellular Cardiology·K SchwartzB Swynghedauw

❮ Previous
Next ❯

Citations

Aug 1, 1995·Journal of Muscle Research and Cell Motility·C A LucasJ F Hoh
Jun 1, 1995·Clinical and Experimental Pharmacology & Physiology·G H RossmanithJ F Hoh
Sep 30, 1996·Annals of the New York Academy of Sciences·J N Peterson, N R Alpert
Dec 22, 1999·The American Journal of Physiology·T IshikawaS Kurihara
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J BaxiC L Gibbs
Sep 22, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Joseph F Y HohWendy W H Zhong
Jul 31, 2012·Biochemistry Research International·Kerry S McDonaldCraig A Emter
Oct 20, 2015·Biomechanics and Modeling in Mechanobiology·M B Rubin
Aug 1, 1986·Journal of Muscle Research and Cell Motility·G H Rossmanith
May 12, 1998·The American Journal of Physiology·D GeorgakopoulosD A Kass
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·G H Rossmanith, O B Tjokorda
Mar 10, 1999·Cardiovascular Research·T RufC Holubarsch
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T WannenburgP P De Tombe
Sep 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Carmit Levy, Amir Landesberg
Jun 15, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Joseph F Y HohWendy W H Zhong
Dec 17, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Wendy W H ZhongJoseph F Y Hoh
Apr 15, 2006·Pflügers Archiv : European journal of physiology·Oleg AndruchovStefan Galler
Jun 2, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yoonah KimJoseph F Y Hoh
Mar 6, 2008·Journal of Muscle Research and Cell Motility·Joseph F Y HohGunther H Rossmanith
Nov 24, 1999·Journal of Applied Physiology·M V RazumovaK B Campbell
Jun 1, 1988·Journal of Muscle Research and Cell Motility·A J FarrowJ Unsworth
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Kenneth B CampbellWilliam C Hunter
Nov 3, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Joseph F Y HohWendy W H Zhong
Oct 24, 1998·Progress in Biophysics and Molecular Biology·P J HunterH E ter Keurs
Dec 13, 2005·Biophysical Journal·S A NiedererN P Smith
Jan 25, 2013·Biochemistry·Thomas P Burghardt, Laura A Sikkink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.