PMID: 10390Sep 1, 1976

Influence of various substances on prostaglandin biosynthesis by guinea-pig chopped lung

The Journal of Pharmacy and Pharmacology
B Fjalland

Abstract

Guinea-pig chopped lung tissue was used to investigate the inhibitory effect of various steroidal and non-steroidal anti-inflammatory agents, antipyretics, analgesics, local anaesthetics and psychotropic drugs on mechanically induced release of prostaglandin-like material. Low concentrations of non-steroidal anti-inflammatory agents inhibited synthesis, but other antipyretics and analgesics, and the local anaesthetics had little effect. Thymoleptics, neuroleptics and monoamine oxidase inhibitors except phenelzine exhibited weak activity. It is concluded that the method is a useful pharmacological model to study prostaglandin biosynthesis. The weak effects of the psychotropic drugs suggest that they do not exert their clinical effect by inhibiting PG biosynthesis.

References

Nov 1, 1975·The Journal of Pharmacy and Pharmacology·H KunzeG Bahrke
Oct 11, 1975·Lancet·I L StrannegårdO Strannegård
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A HamF A Kuehl
Mar 15, 1975·Experientia·P Krupp, M Wesp
Apr 30, 1971·Annals of the New York Academy of Sciences·P J Piper, J R Vane
Nov 1, 1974·Nature·H O CollierS A Saeed
Jul 26, 1972·Nature: New Biology·R J FlowerJ R Vane
May 15, 1974·Biochemical Pharmacology·R J Flower, J R Vane
Apr 8, 1972·British Medical Journal·M W Greaves, W McDonald-Gibson
Jun 22, 1968·Nature·N GilmoreJ H Wyllie

Citations

Apr 1, 1983·Prostaglandins, Leukotrienes, and Medicine·J LiebD F Horrobin
Nov 1, 1980·Prostaglandins and Medicine·B Lambert, C Jacquemin
Feb 1, 1980·British Journal of Clinical Pharmacology·G SacchettiV Mandelli

Related Concepts

Antinociceptive Agents
Anti-Inflammatory Agents
Depression, Chemical
Cavia porcellus
Lung
Prostaglandins
Psychotropic Drugs

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