PMID: 9525761Apr 3, 1998Paper

Influence of vasoactive drugs on wall shear stress distribution in the abdominal aortic bifurcation: an in vitro study

Annals of Biomedical Engineering
C S Lee, J M Tarbell

Abstract

The present study compares the wall shear stress (rate) distribution in a compliant aortic bifurcation model under three different hemodynamic states: normal state, angiotensin II infusion state (vasoconstrictor), and isoproterenol infusion state (vasodilator). Using a Newtonian blood analog fluid, flow wave forms corresponding to each flow state were generated in an in vitro flow loop and a photographic flow visualization technique was employed to measure wall shear rate. The results indicate a zone of low mean wall shear stress and highly oscillatory shear stress on the outer (lateral) wall of the bifurcation. In this zone, the mean wall shear stress became negative for all three hemodynamic states indicating flow separation. However, the spatial extent of the flow separation zone was not affected significantly by the flow state. The study also revealed a large spatial variation of the phase angle between the hoop strain (circumferential strain due to radial artery expansion) and the wall shear stress, the two main mechanical stimuli acting on endothelial cells which affect their biology. In the zone of low mean wall shear stress on the outer wall, the two stimuli were more out of phase relative to the mother branch, whereas ...Continue Reading

Citations

Nov 24, 2001·Medical Engineering & Physics·Y LiuK B Chandran
May 3, 2000·Journal of Biomechanical Engineering·Y Qiu, J M Tarbell
Mar 4, 2018·Biomedical Engineering Online·Lili NiuHairong Zheng
Feb 18, 2010·Cellular and Molecular Bioengineering·Danielle E Berardi, John M Tarbell

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