PMID: 2106798Feb 1, 1990Paper

Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin

The American Journal of Physiology
F W SellkeD G Harrison

Abstract

The responses of small (60-100 microns), medium (101-190 microns), and large (191-300 microns) porcine coronary microvessels to nitroglycerin were examined in vitro using a video-imaging apparatus. Large coronary microvessels, preconstricted with acetylcholine, relaxed by 90% in response to nitroglycerin, whereas small microvessels relaxed only 20% to nitroglycerin. Responses to putative metabolites of nitroglycerin, S-nitrosocysteine, and nitric oxide, were also examined. S-Nitrosocysteine produced equal relaxations in all sizes of coronary microvessels. Nitric oxide was 10 times more potent in large coronary arteries than in small but produced greater than 90% relaxation of all sizes of coronary microvessels at the highest concentrations. Bradykinin and the calcium ionophore A23187, which release endothelium-derived relaxing factor (EDRF), produced similar relaxation in small, medium, and large microvessels. The compound LY 83583 (which depletes vascular guanylate cyclase) reduced responses to nitroglycerin, nitric oxide, S-nitrosocysteine, bradykinin, and the calcium ionophore A23187 in microvessels of all sizes. Our data are compatible with the concept that nitroglycerin must undergo reductive processing to exert its vasodi...Continue Reading

Citations

Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Michael C PayneSteven A Fisher
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Yi-Hui SunJohn V Tyberg
Dec 4, 2013·Annals of Biomedical Engineering·Eoin R HydeNicolas P Smith
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J R KerstenD C Warltier
Oct 25, 2011·Pflügers Archiv : European journal of physiology·Lei YingYuansheng Gao
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinji AkishimaYuzuru Sakakibara
Aug 26, 2010·Physiological Genomics·Steven A Fisher

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