Influence of Visceral Interoceptive Experience on the Brain's Response to Food Images in Anorexia Nervosa

Psychosomatic Medicine
Kara L KerrW Kyle Simmons

Abstract

The aim of the study was to determine how visceral sensations affect responses to food stimuli in anorexia nervosa (AN). Twenty weight-restored, unmedicated adolescent and young adult women with AN and twenty healthy control participants completed an interoceptive attention task during which they focused on sensations from the heart, stomach, and bladder and made ratings of these sensations. They then underwent functional magnetic resonance imaging scanning while viewing pictures of food and nonfood objects. Between-groups t tests were employed to investigate group differences in the relationship between interoceptive sensation ratings and brain hemodynamic response to food pictures and, specifically, to highly palatable foods. In response to food pictures, AN participants exhibited a positive relationship between stomach sensation ratings and posterior insula activation (peak t = 4.30). AN participants displayed negative relationships between stomach sensation ratings and amygdala activation (peak t = -4.05) and heart sensation ratings and ventromedial prefrontal cortex activation (peak t = -3.52). In response to highly palatable foods, AN was associated with positive relationships between stomach sensation ratings and activit...Continue Reading

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Citations

Jul 6, 2018·Annals of the New York Academy of Sciences·Lisa QuadtSarah N Garfinkel
Nov 10, 2018·Journal of Eating Disorders·E Caitlin Lloyd, Joanna E Steinglass
Aug 2, 2020·Journal of Affective Disorders·Xiaoqin WangJiang Qiu
Apr 10, 2021·The International Journal of Eating Disorders·Kara L KerrAmanda Sheffield Morris
Aug 28, 2019·Neuroscience and Biobehavioral Reviews·E MartinS Higgs
Jul 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Claire J FoldiBrian J Oldfield

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