Influence of vitamin D receptor haplotypes on blood lead concentrations in environmentally exposed children of Uygur and Han populations

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Yan ChenWei Tian

Abstract

To explore the association between polymorphism of vitamin D receptor (VDR) and lead poisoning in Uygur and Han children in China. The BsmI, ApaI and TaqI restriction sites of VDR genotyping were determined by polymerase chain reaction-restriction fragment length polymorphism in 443 Uygur and 469 Han children from Xinjiang province. The correlation between the polymorphism of VDR haplotypes and blood lead levels was explored. The genotype frequencies of VDR had significant differences in Han and Uygur children (p <0.01). According to VDR-BsmI, ApaI and TaqI haplotype analysis in Han children, haplotypes Atb and AtB were considerably decreased in the lead poisoning group (p <0.05) while haplotype aTb and ATb were significantly increased in the lead poisoning group (p <0.01). However, such results were not found in Uygur children (p < 0.05). A significant difference was seen in the frequency distribution of the VDR genotype among the different races. Haplotypes Atb and AtB might be protective factors while haplotypes ATb and aTb might be risk factors in Han children.

References

Jan 1, 1978·Pediatric Research·E E ZieglerS J Fomon
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N A MorrisonJ A Eisman
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 6, 1973·The New England Journal of Medicine·J S Lin-Fu
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
May 13, 1995·Lancet·H KrögerP Mäenpää
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A TokitaJ A Eisman
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Jun 12, 1998·Brain Research. Brain Research Reviews·Y FinkelsteinJ F Rosen
May 5, 1999·Neurochemical Research·J BresslerG Goldstein
Feb 24, 2001·Epidemiologic Reviews·J M ZmudaR E Ferrell
Jan 30, 2002·The Journal of Pediatrics·Bruce P LanphearShirley Eberle
Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Apr 18, 2003·The New England Journal of Medicine·Richard L CanfieldBruce P Lanphear
Jul 2, 2003·Neurotoxicity Research·Carla Marchetti
Aug 5, 2003·Nature Reviews. Genetics·Jeffrey D Wall, Jonathan K Pritchard
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jun 17, 2004·Environmental Health Perspectives·Karin KollerLen Levy
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Jul 9, 2005·Environmental Health Perspectives·Bruce P LanphearRussell Roberts
Dec 7, 2005·Environmental Health Perspectives·Fernando BarbosaPatrick J Parsons
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian D Juran, Konstantinos N Lazaridis
Apr 24, 2007·Pediatric Clinics of North America·Tee L Guidotti, Lisa Ragain
Aug 19, 2007·Archives of Toxicology·Vania B RezendeJose E Tanus-Santos
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Galina LurieMarc T Goodman

❮ Previous
Next ❯

Citations

Jun 21, 2012·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Xiaohui ZhouKabinur Keyimu
Nov 26, 2020·Human & Experimental Toxicology·Monica Shirley ManiHerman Sunil Dsouza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.