Abstract
Antibiotic entry into the water environment has been of growing concern. However, few investigations have been performed to examine the potential for indirect human exposure to environmental antibiotic residues. We evaluated the contribution of drinking water and major food consumption to inadvertent intake of antibiotic residues among general human population in Korea. We estimated daily human intake of six antibiotics, i.e., sulfamethazine (SMZ), sulfamethoxazole (SMX), sulfathiazole (STZ), trimethoprim (TMP), enrofloxacin (EFX), and roxithromycin (RTM), by measuring the concentrations of the antibiotics and their major metabolites in urine from general population in Korea (n=541). In addition, we measured antibiotics from source water of drinking water as well as in tap water samples, and surveyed water consumption rates among the study population. To assess the contribution of dietary factor, we also surveyed consumption pattern for several major foods which are suspected of antibiotics residue. SMZ, Sulfamethazine-N4-acetyl (SMZ-N4), TMP, EFX, ciprofloxacin (CFX), and RTM were detected up to 448, 6210, 11,900, 6970, 32,400, and 151pg/ml in the urine samples, respectively. Estimates of daily intake of major antibiotics did ...Continue Reading
References
Mar 1, 1990·Antimicrobial Agents and Chemotherapy·C E HalstensonG R Matzke
Mar 7, 1998·Science·W Witte
Mar 2, 1999·Regulatory Toxicology and Pharmacology : RTP·F M Christensen
Nov 30, 2000·Environmental Health Perspectives·M C KohnL L Needham
May 4, 2002·Toxicology Letters·Thomas Heberer
Nov 27, 2002·Water Research·O A H JonesJ N Lester
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lynn O PostMichael J Myers
Mar 1, 2003·Nature·Edward J Calabrese, Linda A Baldwin
Apr 15, 2003·Toxicology Letters·Simon WebbKlaus Olejniczak
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·R VarmaV Ahuja
Jan 10, 2004·Environmental Toxicology and Chemistry·Chris D MetcalfeRoman Hirsch
Jan 10, 2004·Environmental Toxicology and Chemistry·Chris D MetcalfeJohn Struger
Jan 14, 2004·Emerging Infectious Diseases·Leanne UnicombPeter Collignon
Apr 20, 2004·Occupational and Environmental Medicine·S KaurP Steer
Jun 23, 2004·The Science of the Total Environment·Dana W KolpinSteven D Zaugg
Jul 21, 2004·The Science of the Total Environment·Paul E StackelbergDori B Reissman
Jun 7, 2005·The Science of the Total Environment·Paul H Roberts, Kevin V Thomas
Jun 28, 2005·Regulatory Toxicology and Pharmacology : RTP·Bradley W SchwabPaul D Anderson
Sep 13, 2005·The Veterinary Journal·Marilyn MartinezRobert Walker
Nov 1, 2005·Aquatic Toxicology·Karl FentDaniel Caminada
May 9, 2006·Chemosphere·Ajit K SarmahAlistair B A Boxall
May 16, 2006·The Science of the Total Environment·Lori LishmanPeter Seto
Aug 19, 2006·Environmental Toxicology and Chemistry·Guy L BrunHing-Biu Lee
Aug 21, 2007·Biomedical Chromatography : BMC·Hee-Jung ChoHo-Chul Shin
Jan 19, 2008·Environmental Science & Technology·Gerald T AnkleyJohn P Sumpter
Aug 8, 2008·The Science of the Total Environment·Kyungho ChoiPangyi Kim
Sep 2, 2008·Talanta·Shufang SuXiangchao Dong
Oct 31, 2008·Talanta·M D HernandoD Barceló
Nov 18, 2008·Regulatory Toxicology and Pharmacology : RTP·Virginia L CunninghamMichael J Olson
Mar 17, 2010·Environmental Research·Kyunghee JiKyungho Choi
Citations
Feb 18, 2016·Environment International·Hexing WangQingwu Jiang
Aug 30, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·François GrahamAnne Des Roches
Jun 6, 2015·Gut·Kathryn A KnoopRodney D Newberry
Feb 24, 2017·Environmental Science & Technology·Hexing WangQingwu Jiang
Mar 17, 2015·Talanta·Yusun ZhouYong-Ill Lee
Feb 26, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Z Keli-BhijaC Ponvert
Mar 20, 2019·Scientific Reports·Adriano LamaGiuseppina Mattace Raso
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sandip MondalGangfeng Ouyang
May 17, 2019·Journal of Analytical Toxicology·Xiaoli WangRusong Zhao
May 16, 2013·Journal of Environmental Quality·Maria E Grimmett
Jun 12, 2019·Analytical and Bioanalytical Chemistry·Đorđe TadićJosep M Bayona
Feb 6, 2020·Environmental Monitoring and Assessment·Yungang ShiYunjiang Yu
Oct 6, 2015·Journal of Environmental Quality·Maria E Grimmett
May 29, 2018·Critical Reviews in Biotechnology·Sicheng ShaoYuancai Chen
Mar 29, 2019·Journal of Analytical Methods in Chemistry·Chen LanShusheng Zhang
Oct 22, 2020·Foods·Demetra KyriakidesIrene Panderi
Oct 25, 2020·The Science of the Total Environment·Hoang Quoc AnhThi Anh Huong Nguyen
Aug 12, 2020·Journal of Environmental Management·Hudda Khaleeq KhanRiffat Naseem Malik
Jan 28, 2020·Ecotoxicology and Environmental Safety·Jingjing ZhangKaiyong Liu
Jun 3, 2020·The Science of the Total Environment·Nasrin Naderi BeniShannon Bartelt-Hunt
Mar 2, 2021·Environmental Research·Yi-Jing ZhouXiang Huo
Dec 12, 2018·Environmental Research·Yujie BenChunmiao Zheng
Apr 17, 2021·Journal of Hazardous Materials·Jiaoyang HaoGenxiang Shen
May 1, 2021·Environmental Science and Pollution Research International·Anita KotwaniDeeksha Kaloni
May 1, 2021·Journal of Food Science·Xiaofeng JiMingrong Qian
Sep 11, 2017·Environment International·Na LiWen-Jing Deng
Nov 6, 2018·Environmental Science & Technology·Hexing WangQingwu Jiang
Aug 26, 2021·Heliyon·Md Sahidur RahmanSharmin Chowdhury
Sep 2, 2021·The Science of the Total Environment·Chaomeng DaiLang Zhou