Influence of Weight Reduction and Enhanced Protein Intake on Biomarkers of Inflammation in Older Adults with Obesity

Journal of Nutrition in Gerontology and Geriatrics
Kathryn N Porter StarrConnie W Bales

Abstract

Both aging and obesity are associated with increased levels of pro-inflammatory metabolites, while weight reduction is associated with improvements in inflammatory status. However, few studies have explored the response of key inflammatory markers to the combined settings of weight reduction in an aging population. There are also few studies that have investigated the potential impact of diet composition on inflammatory marker responses. In the MEASUR-UP trial, we evaluated changes in baseline levels of inflammatory markers with post-study levels for a traditional weight loss control group versus a group with generous, balanced protein intake. In this 6-month randomized controlled trial (RCT), older (≥60 years) adults with obesity (BMI ≥30 kg/m2) and Short Physical Performance Battery (SPPB) score of 4-10 were randomly assigned to either a traditional weight loss regimen, (Control, n = 14) or one with higher protein intake (≥30 g) at each meal (Protein, n = 25). All participants were prescribed a hypo-caloric diet and attended weekly support and education groups and weigh-ins. Protein participants consumed ≥30 g of high-quality protein/meal, including lean and extra lean beef provided to them for two of the three meals per day....Continue Reading

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Citations

Feb 27, 2019·Journal of Nutrition in Gerontology and Geriatrics·John A Batsis
May 22, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern
Aug 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern

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Methods Mentioned

BETA
Protein Assay

Software Mentioned

MEASUR
RESMENA
SAS
Food Processor Nutrition Analysis Software
UP

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