PMID: 9161920May 1, 1997Paper

Influence of whey and purified whey proteins on neutrophil functions in sheep

The Journal of Dairy Research
C W WongD L Watson

Abstract

The effects of ruminant whey and its purified fractions on neutrophil chemotaxis and superoxide production in sheep were studied. Both colostral whey and milk whey were found to inhibit chemotaxis regardless of whether they were autologous or homologous, but the inhibitory effects were abolished by washing neutrophils with culture medium before their use in the chemotaxis assay. Colostral whey and milk whey also inhibited the chemotactic activity of zymosan-activated serum. Whey fractions of various degrees of purity such as lactoferrin, lactoperoxidase, lactoferrin-lactoperoxidase, alpha-lactalbumin, bovine serum albumin and whey protein concentrate were then studied. While none of these proteins showed any effects on chemotaxis, lactoferrin-lactoperoxidase and whey protein concentrate were found to have an enhancing effect on superoxide production in a dose-dependent manner. Our results provide information on the modulatory role of ruminant milk proteins in inflammatory responses and warrant future investigation.

Citations

Jan 26, 2016·Journal of Dairy Science·J R KanwarG W Krissansen
Dec 25, 2010·Veterinary Immunology and Immunopathology·Branislav LakicKarin Ostensson
Jan 10, 2003·The Journal of Veterinary Medical Science·Hitoshi SugisawaTakeo Sakai
Dec 25, 2008·The Journal of Nutrition·Daniel RusuPatrice E Poubelle
Jan 12, 2008·Journal of the American College of Nutrition·Geoffrey W Krissansen
Mar 10, 2001·The British Journal of Nutrition·M L Cross, H S Gill
Oct 2, 2008·Alternatives to Laboratory Animals : ATLA·Hemen DasTukaram More

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