PMID: 11567883Sep 25, 2001Paper

Influence of X-ray on the autophagic-lysosomal system in rat pancreatic acini

Micron : the International Research and Review Journal for Microscopy
Agnes TelbiszZoltán Somosy

Abstract

Lysosomes have an important role in radiation injury of cells and tissues. Activation of autophagy is frequently observed in different types of pathological tissue degeneration. In radiation response it increases in some cases, and lysosomes are responsible for regulated degradation of the autophagic vacuoles. Lysosomes are also involved in ionizing radiation induced cell death. In apoptosis lysosomes degrade content of the phagocytotic vacuoles derived from engulfed apoptotic blebs. On the other hand lysosomal enzymes discharged from disintegrated cells have a key role in induction of necrotic changes. In this work we investigate autophagy and lysosomal protein degradation in the relatively radiation insensitive exocrine pancreatic acini in vivo and in vitro. Type of cell death induced by X-ray was also examined in relation to the changes of the lysosomal processes. In 5h after 16 Gy in vivo whole body irradiation we observed significant increase in the cytoplasmic volume fraction of autophagic vacuoles and in the number of apoptotic cells in vivo. But in the acini isolated from irradiated rats we could not detect a change in the lysosomal degradation of intracellular proteins. Therefore irradiation probably influences the aut...Continue Reading

References

Jan 1, 1992·Experimental and Clinical Endocrinology·J M BetzoldD K Lüdecke
Jan 1, 1992·Radiation and Environmental Biophysics·P T Salovsky, V L Shopova
Jun 8, 1992·FEBS Letters·J J LuikenA J Meijer
Jul 1, 1991·Experimental Cell Research·A E Arias, M Bendayan
Jul 1, 1990·Journal of Neuroscience Research·G HamdorfA Skoberla
Jan 1, 1987·Annual Review of Nutrition·G E Mortimore, A R Pösö
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·F Ahmadu-SukaC E Whiteman
Jan 1, 1987·Journal of Surgical Oncology·D F Du ToitL B Du Toit
Jan 1, 1970·Advances in Biological and Medical Physics·J W Harris
Oct 1, 1983·International Journal of Radiation Oncology, Biology, Physics·B C ZookC C Rogers
Jun 1, 1995·The Anatomical Record·J Yi, X M Tang
Jan 1, 1997·Toxicologic Pathology·R Schulte-HermannA Ellinger
Aug 5, 1998·International Journal of Radiation Biology·G M PaardekooperA W Konings
Dec 10, 1999·Micron : the International Research and Review Journal for Microscopy·Z Somosy

❮ Previous
Next ❯

Citations

Mar 6, 2008·Histochemistry and Cell Biology·Yasuo UchiyamaMitsuho Sasaki
Jun 29, 2005·Annals of Biomedical Engineering·Taili T ThulaChristopher Batich
Apr 4, 2018·International Journal of Radiation Biology·Anna WieczorekPiotr Widlak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms