Influences of complex organic mixtures on tumor-initiating activity, DNA binding and adducts of benzo[a]pyrene

Carcinogenesis
D L SpringerD D Mahlum

Abstract

Co-incubation of benzo[a]pyrene (BaP) and coal-derived complex organic mixtures has been shown to decrease the metabolism and mutagenic activity of BaP. Because of these influences, five mixtures were co-administered dermally to mice to initiate tumor development. Results from these studies demonstrated that BaP tumor-initiating activity was decreased substantially by four of the five mixtures. When one of the mixtures was separated into chemical class fractions, the polycyclic aromatic hydrocarbon (PAH) and nitrogen-containing polycyclic aromatic compound fractions were the most effective, and the aliphatic and hydroxy-PAH fractions were the least effective as inhibitors of BaP-induced tumor initiation. Binding of [3H]BaP to epidermal DNA under conditions identical to those used for tumor initiation was decreased by co-administration of all five mixtures. Calculations of the number of tumors produced/micrograms BaP bound to DNA demonstrated that co-administration of this carcinogen with the mixtures consistently increased the effectiveness of the bound BaP at producing tumors by approximately a factor of 2. The HPLC radioactivity profiles of enzyme-hydrolyzed, adducted DNA indicated that, in the presence of the mixtures, the p...Continue Reading

Citations

Apr 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E OvervikJ A Gustafsson
Dec 1, 1993·Journal of Toxicology and Environmental Health·J R WitheyL Endrenyi
May 1, 1994·Journal of Toxicology and Environmental Health·E H WeyandL Goldstein
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·D B MannM J Smerdon
Dec 26, 2006·International Journal of Cancer. Journal International Du Cancer·Brinda MahadevanWilliam M Baird
Feb 7, 2017·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Michiko T YasudaKayoko Shimoi
Jul 27, 2000·Carcinogenesis·A KogantiE H Weyand

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