Abstract
Many studies have reported an association between diabetes and hearing loss. However, these reports were mainly abstractive correlations between common hearing loss and the incidence of diabetes. Therefore, we evaluated the impact of diabetes on the occurrence of and recovery from noise-induced hearing loss. We used 5-week-old C57BLKS/J-m wild type (+/+) and C57BLKS/J-db/db male mice as the control and diabetic groups, respectively. In one set of experiments, the hearing levels of control and diabetic mice were measured weekly for 7 weeks. In a second set of experiments, control and diabetic mice were exposed to broadband white noise of 110 dB SPL for 3 hours; hearing levels were analyzed before and immediately after exposure, 1, 3, and 5 days, and 1, 2, 3, and 4 weeks after the noise exposure. The hearing levels of the control group were better than those of the diabetic group at each weekly revision for 7 weeks at all auditory brainstem response frequencies (4, 8, 16, and 32 kHz). After noise exposure, both groups of mice showed an immediate increase in the hearing level threshold at all frequencies. Subsequent threshold recovery was seen in both groups with no difference in the hearing level recovery rates between the two gr...Continue Reading
References
Dec 15, 1992·The Science of the Total Environment·E K IshiiL H Kuller
Apr 1, 1971·The Annals of Otology, Rhinology, and Laryngology·K Makishima, K Tanaka
Jan 1, 1996·Auris, Nasus, Larynx·O CelikA Oztürk
May 26, 1999·The Journal of Laryngology and Otology·C T McQueenH C Pillsbury
Dec 17, 2002·European Journal of Clinical Pharmacology·Maria Paula MarquesVera Lucia Lanchote
Jun 14, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Venkata KakarlapudiHinrich Staecker
Dec 17, 2005·Antioxidants & Redox Signaling·Pál Pacher, Csaba Szabó
Sep 20, 2006·Archives of Otolaryngology--head & Neck Surgery·Hisaki FukushimaMehmet F Oktay
Mar 3, 2007·Journal of Diabetes and Its Complications·Pedro RomeroInmaculada Martinez
Jun 19, 2008·Annals of Internal Medicine·Kathleen E BainbridgeCatherine C Cowie
Jul 16, 2008·Atherosclerosis·Jingyu SongKatsuo Sueishi
Dec 19, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yuri AgrawalJohn K Niparko
Apr 10, 2009·The Laryngoscope·Hung-Pin WuChuan-Jen Hsu
Jul 14, 2009·The Laryngoscope·Donald F AustinStephen Fausti
Aug 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·P MitchellS R Leeder
Aug 12, 2009·Preventive Medicine·Yiling J ChengAnn L Albright
Aug 2, 2012·Diabetes·Takeshi FujitaKen-Ichi Nibu
Apr 2, 2014·Advances in Wound Care·Paul W Ackermann, David A Hart
Sep 4, 2014·BMC Research Notes·Steven JamesLin Perry