Influences of niobium pentoxide on roughness, hydrophilicity, surface energy and protein absorption, and cellular responses to PEEK based composites for orthopedic applications.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Junpeng GeJie Wei

Abstract

To improve the bio-performances of polyetheretherketone (PEEK) for orthopedic applications, submicro-particles of niobium pentoxide (Nb2O5) were synthesized using a sol-gel method, and PEEK/Nb2O5 composites (PNC) with a Nb2O5 content of 25v% (PNC25) and 50v% (PNC50) were fabricated by utilizing a process of pressing-sintering. The results showed that the Nb2O5 particles were not only dispersed in the composites but also exposed on the surface of the composites, which formed submicro-structural surfaces. In addition, the hydrophilicity, surface energy, surface roughness and absorption of proteins of the composites were improved with increasing Nb2O5 content. Moreover, the release of Nb ions with the highest concentration of 5.01 × 10-6 mol L-1 from the composite into the medium displayed no adverse effects on cell proliferation and morphology, indicating no cytotoxicity. Furthermore, compared with PEEK, the composites, especially PNC50, obviously stimulated adhesion and proliferation as well as osteogenic differentiation of bone mesenchymal stem cells of rats. The results suggested that the incorporation of Nb2O5 submicro-particles into PEEK produced novel bioactive composites with improved surface properties, which played impor...Continue Reading

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Citations

Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou
Apr 27, 2021·Advanced Science·Kaiyi SuFeng Wang
Oct 7, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Mark A RambaranC André Ohlin

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Methods Mentioned

BETA
scanning
transmission
dynamic
X-ray
differential scanning calorimetry
Assay
transmission electron microscopy

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