Abstract
Re Du Ning Injection (RDN), a traditional Chinese medicine injection, is made from the extracts of Lonicerae japonicae flos (LJF), Artemisiae annuae herba (AAH) and Gardeniae fructus (GF). Since last decade, RDN has been widely used in China for the treatment of fever, inflammation, allergy and viral infection. To elucidate the potential influences of RDN on the activities of four cytochrome P450 (CYP) isozymes in rats (CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2) by "cocktail method". A sensitive and specific LC-MS method capable of simultaneous quantification of four substrates and their metabolites in rat plasma was developed and validated. Relative activity estimation of four isozymes was carried out by comparing plasma pharmacokinetics of substrates and their metabolites (phenacetin/ paracetamol for CYP1A2, tolbutamide/4-hydroxytolbutamide for CYP2C11, dextromethorphan/ dextrorphan for CYP2D1 and dapsone/N-acetyl dapsone for CYP3A1/2) between control and RDN treatment groups. Compared with control group, RDN at different levels could increase the total amount of tolbutamide, dextromethorphan and dapsone absorbed into blood, while decrease the total amount of phenacetin absorbed into blood at low and medium dosage and increase it ...Continue Reading
References
Apr 20, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J J BogaardsB Walther
Dec 28, 2002·Journal of Medicinal Chemistry·Jennifer VenhorstNico P E Vermeulen
Jul 2, 2003·Pharmacogenomics·David F V Lewis
Apr 6, 2004·Trends in Pharmacological Sciences·Magnus Ingelman-Sundberg
Dec 8, 2004·Current Topics in Medicinal Chemistry·Ann K Daly
Sep 20, 2005·Journal of Ethnopharmacology·Hye-Jin KooEun-Hee Park
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Satoshi MishimaTakashi Sakamoto
Apr 6, 2006·Biopharmaceutics & Drug Disposition·Dae Y LeeMyung G Lee
Jul 1, 2006·Journal of Ethnopharmacology·Tran Manh HungKiHwan Bae
Nov 28, 2006·Expert Opinion on Drug Metabolism & Toxicology·Marcella MartignoniRuben de Kanter
Oct 3, 2008·Journal of Separation Science·Dan TangPing Li
Apr 22, 2009·Pharmacy World & Science : PWS·Hou Ming XuNai Feng Liu
Oct 19, 2010·Fitoterapia·S BadalR Delgoda
Nov 15, 2011·Journal of Ethnopharmacology·Yong-Long HanCheng Guo
Feb 11, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Orianne VideauHenri Bénech
Mar 28, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiao-min ChenYong Chen
May 5, 2012·Rapid Communications in Mass Spectrometry : RCM·Yan-Jing LiXue Wang
Mar 26, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Guoliang ZhangWei Xiao
Jun 4, 2014·Biomedical Chromatography : BMC·Chunlei MuQunlin Zhang
Jul 8, 2014·Molecular BioSystems·Xinzhuang ZhangWei Xiao
Citations
Jan 7, 2014·Chinese Medicine·Xuesong YangHutcha Sriplung
May 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Rachumallu RamakrishnaRabi Sankar Bhatta
Nov 29, 2016·Biomedical Chromatography : BMC·Danyu KangWei Xiao
Jan 24, 2018·Electrophoresis·Shengli HanLangchong He
Jan 16, 2020·Pharmaceutics·Hyun Wook HuhAnd Cheong-Weon Cho
Apr 20, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Huan-Hua XuZeng-Chun Ma
Nov 15, 2018·BioMed Research International·Dong ZhangMin-Hui Li
Feb 26, 2019·BioMed Research International·Chen ChengWei Sun
Apr 21, 2019·Metabolites·Xiao PuFengguo Xu
Mar 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wenjuan MaJun He
Jun 1, 2018·Biochemistry Research International·Yiping LinMingxing Ding
Dec 21, 2017·Drug Metabolism Reviews·Peiying ShiHong Yao
Jan 25, 2021·Journal of Ethnopharmacology·Shanshan JiaWei Xiao
Jul 7, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chenxi YangWen Lv
Jul 24, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yun-Jing ZhangJia-Yi Kan
Nov 22, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sicong LiFuqiang Zeng
Aug 15, 2021·Journal of Ethnopharmacology·Yuanyuan ChaiZhenzhou Jiang