Influences of Re Du Ning Injection, a traditional Chinese medicine injection, on the CYP450 activities in rats using a cocktail method

Journal of Ethnopharmacology
Ting GengWei Xiao

Abstract

Re Du Ning Injection (RDN), a traditional Chinese medicine injection, is made from the extracts of Lonicerae japonicae flos (LJF), Artemisiae annuae herba (AAH) and Gardeniae fructus (GF). Since last decade, RDN has been widely used in China for the treatment of fever, inflammation, allergy and viral infection. To elucidate the potential influences of RDN on the activities of four cytochrome P450 (CYP) isozymes in rats (CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2) by "cocktail method". A sensitive and specific LC-MS method capable of simultaneous quantification of four substrates and their metabolites in rat plasma was developed and validated. Relative activity estimation of four isozymes was carried out by comparing plasma pharmacokinetics of substrates and their metabolites (phenacetin/ paracetamol for CYP1A2, tolbutamide/4-hydroxytolbutamide for CYP2C11, dextromethorphan/ dextrorphan for CYP2D1 and dapsone/N-acetyl dapsone for CYP3A1/2) between control and RDN treatment groups. Compared with control group, RDN at different levels could increase the total amount of tolbutamide, dextromethorphan and dapsone absorbed into blood, while decrease the total amount of phenacetin absorbed into blood at low and medium dosage and increase it ...Continue Reading

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Citations

May 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Rachumallu RamakrishnaRabi Sankar Bhatta
Apr 20, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Huan-Hua XuZeng-Chun Ma
Nov 15, 2018·BioMed Research International·Dong ZhangMin-Hui Li
Jun 1, 2018·Biochemistry Research International·Yiping LinMingxing Ding
Jul 7, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chenxi YangWen Lv
Jul 24, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yun-Jing ZhangJia-Yi Kan
Nov 22, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sicong LiFuqiang Zeng

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