Influenza A virus coding regions exhibit host-specific global ordered RNA structure.

PloS One
Salvatore F PrioreDouglas H Turner

Abstract

Influenza A is a significant public health threat, partially because of its capacity to readily exchange gene segments between different host species to form novel pandemic strains. An understanding of the fundamental factors providing species barriers between different influenza hosts would facilitate identification of strains capable of leading to pandemic outbreaks and could also inform vaccine development. Here, we describe the difference in predicted RNA secondary structure stability that exists between avian, swine and human coding regions. The results predict that global ordered RNA structure exists in influenza A segments 1, 5, 7 and 8, and that ranges of free energies for secondary structure formation differ between host strains. The predicted free energy distributions for strains from avian, swine, and human species suggest criteria for segment reassortment and strains that might be ideal candidates for viral attenuation and vaccine development.

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Citations

May 16, 2014·MBio·Julia DuboisManuel Rosa-Calatrava
Sep 12, 2013·PloS One·Salvatore F PrioreDouglas H Turner
Jun 28, 2015·Methods : a Companion to Methods in Enzymology·Walter N Moss, Joan A Steitz
Oct 16, 2012·RNA Biology·Walter N MossDouglas H Turner
Sep 3, 2014·RNA Biology·Alexander P GultyaevRené C L Olsthoorn
Aug 14, 2015·Journal of Virology·Rebecca L Y FanLeo L M Poon
Dec 15, 2016·Scientific Reports·Alexander P GultyaevRon A M Fouchier
Oct 4, 2016·The Biochemical Journal·Agnieszka RuszkowskaElzbieta Kierzek
Feb 6, 2016·PloS One·Elzbieta LenartowiczElzbieta Kierzek
Apr 14, 2018·Frontiers in Microbiology·Damien FerhadianRoland Marquet
Nov 10, 2017·Scientific Reports·Marta Soszynska-JozwiakElzbieta Kierzek

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Software Mentioned

Simmonics package
RNAfold

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