Influenza A virus N5 neuraminidase has an extended 150-cavity

Journal of Virology
Mingyang WangGeorge F Gao

Abstract

There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.

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Citations

Sep 10, 2011·Protein & Cell·Christopher J Vavricka
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Qing LiGeorge F Gao
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xueyong ZhuIan A Wilson
Oct 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Adolfo García-Sastre
Oct 17, 2013·PLoS Pathogens·Suxiang TongRuben O Donis
Mar 4, 2014·Trends in Microbiology·Ying WuGeorge F Gao
Apr 25, 2015·Journal of Pharmaceutical and Biomedical Analysis·Patrick Müller, Kevin M Downard
Sep 22, 2017·The Journal of Infectious Diseases·Joanna A Pulit-PenalozaTaronna R Maines
Jun 6, 2014·Journal of Virology·Xiaoman SunGeorge F Gao
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Sep 22, 2017·The Journal of Infectious Diseases·Larisa V GubarevaJames Stevens
Sep 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis Márquez-DomínguezThomas Scior
Aug 7, 2020·Phytotherapy Research : PTR·Hui-Xian WangPei-Ping Xu
Aug 13, 2020·International Journal of Molecular Sciences·Nanyu HanZunxi Huang
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sphamadla E MtamboHezekiel M Kumalo

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