Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

Journal of Virology
Chi-Jene ChenRong Hai

Abstract

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

References

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Citations

Sep 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jad MaamaryJeffrey V Ravetch
Sep 7, 2018·The Journal of Clinical Investigation·Sean T H LiuPeter Palese
Jul 16, 2020·Vaccines·Sabari Nath NeerukondaCarol D Weiss
Apr 10, 2018·Frontiers in Immunology·Arun KumarSylvie Bertholet
Oct 24, 2019·Pathogens·Shirin StrohmeierFlorian Krammer

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