Influenza A/H1N1 (2009) infection as a cause of unexpected out-of-hospital death in the young.

Journal of Forensic Sciences
Camille BoulagnonPaul Fornes

Abstract

In March 2009, a new strain of influenza A/H1N1 virus was identified in Mexico, responsible for a pandemic. Worldwide, more than 13,500 patients died, most often from acute respiratory distress syndrome. Because sudden death cases were rare, involving mostly young apparently healthy persons, influenza A/H1N1 (2009)-related deaths may be misdiagnosed, which can raise medico-legal issues. we report on an unexpected out-of-hospital death involving a young male with no past medical history and no vaccination. Fever was his only symptom. Laboratory tests: histology showed patchy necrotic foci with mononuclear inflammation in the lungs. The heart was histologically normal, but virological analyses using molecular biology on frozen myocardial samples showed high virus load. In conclusion, this case report shows that influenza A/H1N1 (2009) virus can be a cause of sudden cardiac death in the young and demonstrates the importance of quantitative virological analyses for the diagnosis of myocarditis.

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Citations

Jun 17, 2014·Internal Medicine·Jiro FujitaMasao Tateyama
Feb 24, 2016·Expert Review of Anti-infective Therapy·Magali GarciaNicolas Lévêque
Dec 3, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D Leoni, J Rello

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Methods Mentioned

BETA
Assay
PCR
biopsy
biopsies

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