Influenza in Asthmatics: For Better or for Worse?

Frontiers in Immunology
Raja VeerapandianAmali E Samarasinghe

Abstract

Asthma and influenza are two pathologic conditions of the respiratory tract that affect millions worldwide. Influenza virus of the 2009 pandemic was highly transmissible and caused severe respiratory disease in young and middle-aged individuals. Asthma was discovered to be an underlying co-morbidity that led to hospitalizations during this influenza pandemic albeit with less severe outcomes. However, animal studies that investigated the relationship between allergic inflammation and pandemic (p)H1N1 infection, showed that while characteristics of allergic airways disease were exacerbated by this virus, governing immune responses that cause exacerbations may actually protect the host from severe outcomes associated with influenza. To better understand the relationship between asthma and severe influenza during the last pandemic, we conducted a systematic literature review of reports on hospitalized patients with asthma as a co-morbid condition during the pH1N1 season. Herein, we report that numerous other underlying conditions, such as cardiovascular, neurologic, and metabolic diseases may have been underplayed as major drivers of severe influenza during the 2009 pandemic. This review synopses, (1) asthma and influenza independe...Continue Reading

References

Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
May 1, 1991·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·A M Saavedra-Delgado, S G Cohen
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Jan 1, 1982·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S G Marketos, C N Ballas
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·A WannerT G O'Riordan
Dec 1, 1996·Journal of Virology·S Schultz-Cherry, V S Hinshaw
Jan 9, 1999·Clinical Microbiology Reviews·J E Gern, W W Busse
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·P G WoodruffJ V Fahy
Jan 25, 2002·Respiratory Research·Jens M Hohlfeld
Apr 17, 2002·The American Journal of Medicine·Arnold S Monto
May 1, 1964·The Journal of Allergy·E L KEENEY
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koenraad F van der SluijsTom van der Poll
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Nov 2, 2004·The European Respiratory Journal·N C ThomsonE Livingston
Nov 18, 2004·Immunological Reviews·Marsha Wills-Karp
May 20, 2005·American Journal of Respiratory Cell and Molecular Biology·Michael J Walter, Michael J Holtzman
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jodie L SimpsonPeter G Gibson
Feb 24, 2006·Emerging Infectious Diseases·Paul G ThomasPeter C Doherty
Apr 20, 2006·Nature Immunology·Peter C DohertyPaul G Thomas
Jul 15, 2006·Journal of Virology·Prasith BaccamAlan S Perelson
Feb 28, 2007·Immunology and Cell Biology·Toluwalope MakindeDevendra K Agrawal
Apr 24, 2007·Current Allergy and Asthma Reports·Clare M Lloyd
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiki ShiraishiAkitoshi Ishizaka
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Daniel J JacksonRobert F Lemanske
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Tim J T SutherlandD Robin Taylor
Sep 9, 2008·American Journal of Respiratory and Critical Care Medicine·Pingsheng WuTina V Hartert
Nov 19, 2008·The Journal of Allergy and Clinical Immunology·John T Kelly, William W Busse
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Sarah L AppletonUNKNOWN North West Adelaide Cohort Health Study Team
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Claudia E KuehniMichael Silverman
Aug 7, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Celeste PorsbjergVibeke Backer
Aug 29, 2009·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·L VaillantUNKNOWN epidemic intelligence team at InVS
Sep 12, 2009·The New England Journal of Medicine·Kathy HancockJacqueline M Katz
Sep 22, 2009·Immunity·Bart N Lambrecht, Hamida Hammad
Oct 10, 2009·The New England Journal of Medicine·Seema JainUNKNOWN 2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team
Nov 6, 2009·JAMA : the Journal of the American Medical Association·Janice K LouieUNKNOWN California Pandemic (H1N1) Working Group
Nov 17, 2009·Current Opinion in Allergy and Clinical Immunology·Teal S Hallstrand, William R Henderson
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle D TatePatrick C Reading
Nov 21, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sean O'RiordanDat Tran
Nov 26, 2009·Critical Care Medicine·Michael B Rothberg, Sarah D Haessler

❮ Previous
Next ❯

Citations

May 30, 2019·Viral Immunology·Armando S Flores-TorresAdrian G Rosas-Taraco
May 10, 2020·Journal of Leukocyte Biology·Kim S LeMessurierAmali E Samarasinghe
Oct 23, 2018·Medicina·Lina JankauskaitėRimantas Kėvalas
May 22, 2020·Human Vaccines & Immunotherapeutics·Andrea Aida Velasco-MedinaRosa María Wong-Chew
Oct 13, 2020·Vaccine·Alejandro E MaciasHongjie Yu
Mar 18, 2021·Seminars in Immunopathology·Helene F Rosenberg, Paul S Foster
Oct 27, 2020·Frontiers in Immunology·Helen E RichMichelle L Manni
Feb 24, 2019·International Journal of Biological Macromolecules·M DutotP Devillier
Apr 20, 2021·ACS Biomaterials Science & Engineering·Daniel SongGregg A Duncan
Sep 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Efrén Murillo-ZamoraOliver Mendoza-Cano

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
transgenic

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.