Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells.

Human Immunology
Erik L BrincksThomas S Griffith

Abstract

The immunologic response to influenza virus infection, like many other viruses, is characterized by robust production of proinflammatory cytokines, including type I and II interferon (IFN), which induce a number of antiviral effects and are essential for priming the innate and adaptive cellular components of the immune response. Here, we demonstrate that influenza virus infection induces the expression of functional tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on human peripheral blood mononuclear cell (PBMC) populations. Consistent with previous studies examining TRAIL upregulation, increased TRAIL expression correlated with increased type I and II IFN levels in PBMC cultures. Interestingly, dilution of these cytokines resulted in decreased expression of TRAIL. TRAIL upregulation was not dependent on active viral infection, and TRAIL was observed on NS-1-negative cells. Furthermore, influenza virus infection of lung adenocarcinoma cells (A549) resulted in increased sensitization to TRAIL-induced apoptosis compared with uninfected A549. Infected PBMC expressing TRAIL preferentially killed infected A549, but did not affect uninfected cells, and the addition of soluble TRAIL-R2:Fc blocked the lysis of infected ...Continue Reading

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Citations

May 15, 2012·In Vitro Cellular & Developmental Biology. Animal·Keiko Shimizu-NishikawaAkio Nishikawa
Mar 30, 2010·Veterinary Microbiology·Channakeshava Sokke UmeshappaAwadh Bihari Pandey
Feb 16, 2013·Seminars in Cancer Biology·Erik L BrincksThomas S Griffith
Dec 31, 2008·Cell Communication and Signaling : CCS·Matthias VossOttmar Janssen
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacqueline UnsingerThomas A Ferguson
Feb 22, 2012·Journal of Leukocyte Biology·Susanne HeroldThorsten Wolff
Jun 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria MgbemenaSantanu Bose
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masafumi SekiTheodore J Standiford
Sep 27, 2018·Frontiers in Immunology·Sophia Davidson
Mar 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erik L BrincksDavid L Woodland
Aug 14, 2018·Frontiers in Medicine·Adam T BraithwaiteAllan Lawrie

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