Influenza-like viral illnesses and flare-ups of fibrodysplasia ossificans progressiva

Clinical Orthopaedics and Related Research
Richard F ScarlettF S Kaplan

Abstract

Flare-ups of fibrodysplasia ossificans progressiva are most commonly triggered by soft tissue trauma. After observing severe flare-ups of fibrodysplasia ossificans progressiva in two half-sisters with culture-confirmed influenza B infections, we hypothesized that influenza-like viral illnesses also can trigger fibrodysplasia ossificans progressiva flare-ups. To address this hypothesis, we designed a questionnaire to assess whether patients with fibrodysplasia ossificans progressiva experienced influenza symptoms during the 2000 to 2001 influenza season, and whether these symptoms were correlated with flare-ups of the condition. The questionnaire was sent to patients with fibrodysplasia ossificans progressiva worldwide. Of the 264 patients surveyed, 123 (47%) responded. The survey revealed that the risk of a disease flare-up of fibrodysplasia ossificans progressiva during an influenza-like viral illness was increased at least threefold and possibly much more. The survey data strongly supported the hypothesis that influenza-like viral illnesses are associated with disease flare-ups in patients who have fibrodysplasia ossificans progressiva. Influenza-like viral illnesses may be a source of previously unrecognized muscle injury le...Continue Reading

References

Jan 1, 1982·The Journal of Bone and Joint Surgery. British Volume·J M Connor, D A Evans
Feb 1, 1993·The Journal of Bone and Joint Surgery. American Volume·F S KaplanM A Zasloff
Aug 1, 1993·The Journal of Bone and Joint Surgery. American Volume·F S KaplanM A Zasloff
Aug 22, 1996·The New England Journal of Medicine·A B ShafritzF S Kaplan
Oct 1, 1996·Australian and New Zealand Journal of Public Health·L L Lim, T Dobbins
Feb 28, 1998·Immunologic Research·A J CatonF F Shih
Dec 22, 1999·Neurology·M T MackayX Dennett
Nov 23, 2000·Archives of Internal Medicine·A S MontoJ Schweinle
Dec 15, 2000·The New England Journal of Medicine·R B Couch

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Citations

Nov 26, 2008·Nature Medicine·Paul B YuKenneth D Bloch
Nov 4, 2008·Journal of Bone and Mineral Metabolism·Frederick S KaplanEileen M Shore
Sep 6, 2011·Clinical Nuclear Medicine·Sumeet G DuaVenkatesh Rangarajan
Dec 2, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael P WhyteSteven Mumm
Aug 13, 2010·Nature Reviews. Rheumatology·Eileen M Shore, Frederick S Kaplan
Jul 4, 2012·Journal of Neurology·Joseph A KittermanFrederick S Kaplan
Jun 26, 2010·European Journal of Pediatrics·Mutlu Kartal-KaessMelchior Lauten
Mar 31, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert J PignoloFrederick S Kaplan
Feb 18, 2015·Current Osteoporosis Reports·Michael R ConventeEileen M Shore
Feb 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Frederick S KaplanStephen G Emerson
May 5, 2007·Expert Opinion on Biological Therapy·Frederick S KaplanEileen M Shore
Oct 16, 2016·Arthritis & Rheumatology·Rebecca BaumEllen M Gravallese
Nov 16, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Melissa LaBonty, Pamela C Yelick
Oct 8, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael R ConventeEileen M Shore
Feb 5, 2008·The Journal of Bone and Joint Surgery. American Volume·Gregory K DeirmengianFrederick S Kaplan
Jun 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Ryan E MooreJoshua D Auerbach
May 7, 2014·Expert Opinion on Orphan Drugs·Frederick S KaplanEileen M Shore
Jul 3, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Devaveena DeyThomas A Davis
Nov 2, 2012·Disease Models & Mechanisms·Frederick S KaplanEileen M Shore
Oct 19, 2005·Pediatrics·Joseph A KittermanFrederick S Kaplan

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