Influenza vaccination as a novel means of preventing coronary heart disease: Effectiveness in older adults.

Vaccine
Amal AidoudBertrand Fougère

Abstract

Atherosclerosis can have various etiologies, including several newly recognized immunoinflammatory mechanisms. A growing body of evidence suggests that influenza infection is chronologically linked to acute myocardial infarction (AMI), and thus that the virus is a novel cardiovascular disease (CVD) risk factor. Morbidity and mortality rates for both influenza infection and AMI rise markedly with age. Epidemiological studies have demonstrated that influenza vaccination (IV) has a cardioprotective effect, especially in people aged 65 and over; hence, IV may be of value in the management of CVD. These observations justify efforts to better understand the underlying mechanisms and to identify therapeutic targets in older adults. In view of the above, the objective of the present study was to review the literature data on the cellular mechanisms that link IV to the prevention of atherosclerotic complications. Given the greater burden of CVD in older subjects, we also questioned the impact of aging on this association. The most widely recognized benefit of IV is the prevention of influenza infection and the latter's cardiovascular complications. In a new hypothesis, however, an influenza-independent effect is driven by vaccine immuni...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·C G FabricantC R Minick
Oct 1, 1995·Annals of Internal Medicine·P A GrossR A Levandowski
Jan 14, 1999·The New England Journal of Medicine·R Ross
Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·P S ThomasD H Yates
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S ZahlerB F Becker
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Feb 2, 2002·Stroke; a Journal of Cerebral Circulation·Philippa LavalléePierre Amarenco
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Jerry H GurwitzDavid W Bates
Apr 4, 2003·The New England Journal of Medicine·Kristin L NicholMarika Iwane
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
Nov 4, 2004·JAMA : the Journal of the American Medical Association·A C G VoordouwBruno H Ch Stricker
Dec 17, 2004·The New England Journal of Medicine·Liam SmeethPatrick Vallance
Jan 18, 2005·Experimental Physiology·Julie Chao, Lee Chao
Feb 22, 2005·Autoimmunity Reviews·Victor S Gurevich
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jun 11, 2005·Stroke; a Journal of Cerebral Circulation·Armin J GrauFlorian Buggle
Oct 3, 2006·Human Vaccines·James D HeffelfingerLisa A Jackson
Oct 7, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Cara L CartyGail P Jarvik
Nov 14, 2006·Vaccine·Chong-Shan WangPesus Chou
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Luis M Blanco-ColioJesus Egido
Jun 5, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·René FerreraMichel Ovize
May 16, 2008·Human & Experimental Toxicology·Mark P Mattson
Jun 24, 2008·Inflammation·Xiu-Ru GuanHong-Yuan Li
May 26, 2009·The American Journal of Cardiology·Jonathan AfilaloHoward Bergman
Sep 26, 2009·The Lancet Infectious Diseases·Charlotte Warren-GashAndrew C Hayward
Feb 2, 2010·The Lancet Infectious Diseases·Vicente F Corrales-MedinaDaniel M Musher
Oct 28, 2010·Nature Reviews. Cardiology·Jerome L FlegWilliam H Frishman
Feb 4, 2011·European Heart Journal·Arintaya PhrommintikulApichard Sukonthasarn
Apr 22, 2011·Atherosclerosis·Alexandra Bermúdez-Fajardo, Ernesto Oviedo-Orta
Nov 16, 2011·Hypertension·Marie Gerhard-HermanLeslie B Gordon

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