PMID: 6162083Jan 1, 1980Paper

Influenza vaccination in HBsAg positive chronic active hepatitis patients treated with interferon

Medical Microbiology and Immunology
R A HeijtinkS W Schalm

Abstract

Sixteen patients with hepatitis B antigen (HBsAg) positive chronic active hepatitis (CAH) were vaccinated with the nonhuman influenza A virus Heq1Neq1; eight patients were also treated with leucocyte interferon. Pre-vaccination sera were negative for specific antibody in hemagglutination inhibition tests. Four weeks after vaccination all patients had responded with a homologous antibody titer. Between the interferon-treated and the untreated groups the differences in antibody titers against the vaccine virus were not significant. Concomitant with the antibody response against the nonhuman influenza virus, a fourfold or higher antibody rise was observed against the influenza A virus strains Hsw1N1 (in six treated with seven untreated patients), H1N1 (in six treated and four untreated patients) and H3N2 (in five treated patients only). The results suggest that a normal specific antibody response in HBsAg positive chronic active hepatitis patients is not significantly altered by leucocyte interferon, and that non-specific antibody production can occur in the absence of a serologic relationship.

Citations

Jun 1, 1986·Digestive Diseases and Sciences·T K TsangR Decker
Mar 1, 1983·European Journal of Pediatrics·S Levin
Jan 1, 1981·Archives of Virology·A Billiau
Apr 1, 1989·Journal of Comparative Pathology·J C ThompsonG H Bell

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