Influenza Vaccination in Italian Healthcare Workers (2018-2019 Season): Strengths and Weaknesses. Results of a Cohort Study in Two Large Italian Hospitals

Vaccines
Donatella Panatto Ciri-It Team

Abstract

Annual vaccination is the most effective way to combat influenza. As influenza viruses evolve, seasonal vaccines are updated annually. Within the European project Development of Robust and Innovative Vaccine Effectiveness (DRIVE), a cohort study involving Italian healthcare workers (HCWs) was carried out during the 2018-2019 season. Two aims were defined: to measure influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza cases and to conduct an awareness-raising campaign to increase vaccination coverage. Each subject enrolled was followed up from enrollment to the end of the study. Each HCW who developed ILI was swabbed for laboratory confirmation of influenza. Influenza viruses were identified by molecular assays. A Cox regression analysis, crude and adjusted for confounding variables, was performed to estimate the IVE. Among the 4483 HCWs enrolled, vaccination coverage was 32.5%, and 308 ILI cases were collected: 23.4% were positive for influenza (54.2% A(H1N1) pdm09; 45.8% A(H3N2)). No influenza B viruses were detected. No overall IVE was observed. Analyzing the subtypes of influenza A viruses, the IVE was estimated as 45% (95% CI: -59 to 81) for A(H1N1) pdm09. Vaccination coverage among HCWs increased. ...Continue Reading

References

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Citations

Aug 18, 2020·Critical Care : the Official Journal of the Critical Care Forum·Giancarlo CeccarelliGabriella d'Ettorre
Jun 4, 2020·International Journal of Environmental Research and Public Health·Manuel MaffeoSilvana Castaldi
Sep 24, 2020·Vaccines·Claudio CostantinoVincenzo Restivo
Apr 29, 2020·Indian Journal of Orthopaedics·Ajay Gupta
Nov 28, 2020·BMC Public Health·M SupinoA Dal Co
Dec 16, 2020·Journal of Biomolecular Structure & Dynamics·Vladislav V KhrustalevValery G Lugin

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Datasets Mentioned

BETA
EPI849370
EPI1151840

Methods Mentioned

BETA
PCR

Software Mentioned

BioEdit
DRIVE
Stata
ClustalW
MEGA
Filemaker Server
INFLUNET

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