Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner

Cell Reports
Yagmur FarsakogluSantiago F Gonzalez

Abstract

The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leads to their early production of IFNγ, which in turn regulates the recruitment of IL-6+ CD11b+ dendritic cells. Finally, we demonstrate that the interleukin-6 (IL-6)-mediated inflammation is important for the development of an effective humoral response against influenza virus in the draining LN.

Citations

Dec 5, 2019·Viral Immunology·Ivayla E GyurovaStephen N Waggoner
Dec 12, 2019·Frontiers in Immunology·Diego Ulisse PizzagalliSantiago F Gonzalez
Jun 9, 2020·Frontiers in Cellular and Infection Microbiology·Stephen PierceTodd Bradley
Jul 24, 2020·Vaccines·Calum ForrestVictoria Male
Jun 17, 2020·Frontiers in Genetics·Hongchun ZhaoQingyin Zheng
Nov 28, 2020·Frontiers in Immunology·Jorge SanchezBehazine Combadiere
Mar 19, 2021·World Journal of Microbiology & Biotechnology·Guanghai YuWeiyun Guo
Jul 28, 2021·Trends in Pharmacological Sciences·Andrew CoxStephen N Waggoner
Nov 20, 2021·Immunological Reviews·Sophia M Vrba, Heather D Hickman

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