Oct 8, 2008

Influenza vaccine effectiveness among children 6 to 59 months of age during 2 influenza seasons: a case-cohort study

Archives of Pediatrics & Adolescent Medicine
Peter G SzilagyiNew Vaccine Surveillance Network

Abstract

To measure vaccine effectiveness (VE) in preventing influenza-related health care visits among children aged 6 to 59 months during 2 consecutive influenza seasons. Case-cohort study estimating effectiveness of inactivated influenza vaccine in preventing inpatient/outpatient visits (emergency department [ED] and outpatient clinic). We compared vaccination status of laboratory-confirmed influenza cases with a cluster sample of children from a random sample of practices in 3 counties (subcohort) during the 2003-2004 and 2004-2005 seasons. Counties encompassing Rochester, New York, Nashville, Tennessee, and Cincinnati, Ohio. Children aged 6 to 59 months seen in inpatient/ED or outpatient clinic settings for acute respiratory illnesses and community-based subcohort comparison. Main Exposure Influenza vaccination. Influenza vaccination status of cases vs subcohort using time-dependent Cox proportional hazards models to estimate VE in preventing inpatient/ED and outpatient visits. During the 2003-2004 and 2004-2005 seasons, 165 and 80 inpatient/ED and 74 and 95 outpatient influenza cases were enrolled, while more than 4500 inpatient/ED and more than 600 outpatient subcohorts were evaluated, respectively. In bivariate analyses, cases h...Continue Reading

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Mentioned in this Paper

Vaccines, Inactivated
Vaccines
Influenza virus vaccine
Hospitalization
Influenza
Incidence Studies
Seasonal Variation
Vaccination
Sex Distribution
Trivalent influenza vaccine

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