Influenza vaccine effectiveness among healthcare workers in comparison to hospitalized patients: a 2004-2009 case-test, negative-control, prospective study

Human Vaccines & Immunotherapeutics
Philippe VanhemsSélilah Amour

Abstract

The objective of this study was to calculate Vaccine Effectiveness (VE) in healthcare workers (HCW) and to compare VE between patients and HCW. A case-control investigation based on the prospective study was conducted between 2004 and 2009 in a teaching hospital. All HCW with influenza-like illness (ILI) from participating units (n=24) were included, and vaccination status was characterized by interview. A total of 150 HCW presented ILI; 130 (87%) were female, 27 (18%) were positive for influenza, and 42 (28%) were vaccinated. Adjusted VE was 89% (95% CI 39 to 98). Among patients, adjusted VE was 42% (95% CI -39 to 76). The difference of VE (VEhcw - VEpat) was 46.15% (95% CI 2.41 to 144). The VE ratio (VEhcw / VEpat) was 2.09 (95% CI -1.60 to 134.17). Influenza VE differed between HCW and patients when the flu season was taken into account. This finding confirms the major impact of host determinants on influenza VE.

References

Mar 17, 1999·JAMA : the Journal of the American Medical Association·J A WildeM C Steinhoff
Jun 15, 2006·Expert Review of Anti-infective Therapy·Antoine Flahault
Dec 15, 2006·The New England Journal of Medicine·Suzanne E OhmitArnold S Monto
Apr 4, 2007·International Journal of Epidemiology·Evan W OrensteinWalter A Orenstein
Aug 27, 2010·Geriatrics & Gerontology International·Masano SagawaNaohito Yamaguchi
Aug 15, 2014·The New England Journal of Medicine·Carlos A DiazGranadosH Keipp Talbot
Nov 20, 2014·The Journal of Infectious Diseases·Huong Q McLeanEdward A Belongia

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Citations

Aug 5, 2016·Healthcare·Helena C Maltezou, Gregory A Poland
Jul 1, 2016·Current Opinion in Infectious Diseases·Philippe VanhemsElodie Munier-Marion
Jun 19, 2019·Future Microbiology·Lara TavoschiPier L Lopalco
Apr 24, 2019·Open Forum Infectious Diseases·Trish M Perl, Thomas R Talbot
May 15, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maxime PichonBruno Lina

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ICE

Software Mentioned

Stata
SPSS

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