Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
A Mira-IglesiasValencia Hospital Network For The Study Of Influenza And Respiratory Viruses Disease

Abstract

IntroductionSeasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vaccine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulating viruses and the vaccine composition. Methods: We summarise the results of IVE and the impact of previous vaccination among subjects 60 years of age and over in a multicentre prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI) in Spain. We applied the test-negative design taking laboratory-confirmed influenza as outcome and vaccination status as exposure. Information about potential confounders was obtained from clinical registries or directly from patients. Results: Adjusted IVE was 19% (95% confidence interval (CI): -15 to 43). For patients vaccinated in the current season but not in the two previous seasons, effectiveness was 49% (95% CI: -20 to 78) and for patients vaccinated in the current and any of two previous seasons, effectiveness was 29% (95% CI: -3 to 52). For those patients not vaccinated in the current season but vaccinated in any of the two previous seasons, effectiveness...Continue Reading

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Citations

Aug 8, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Ainara Mira-Iglesias On Behalf Of The Valencia Hospital Network For The Study Of Influenza And Respiratory Viruses Disease
Nov 26, 2021·Influenza and Other Respiratory Viruses·Ainara Mira-IglesiasUNKNOWN Valencia Hospital Network for the Study of Influenza and other Respiratory Viruses

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Methods Mentioned

BETA
reverse transcription-PCR
glycosylation

Software Mentioned

PhyML
Stata
ClustalW
BioEdit
VRVIS

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