PMID: 9557755Apr 29, 1998Paper

Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes

Journal of Virology
H H NguyenJ Mestecky

Abstract

We have investigated the mechanisms involved in the clearance of viral infection at the epithelium level by analyzing the activity of influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live influenza virus effectively present viral antigens and were lysed by both homotypic and heterotypic influenza virus-specific CD8+ T cells. These results shed new light on the control of viral infection through the elimination of virus-infected epithelial cells by virus-specific CTL and demonstrate that CMT-93 cells furnish an appropriate model for in vitro evaluation of CTL activity against virus-infected epithelial cells.

References

Apr 1, 1978·The Journal of Experimental Medicine·T J Braciale, K L Yap
Feb 1, 1987·The Journal of General Virology·D C WraithB A Askonas
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J W YewdellB Moss
Jul 7, 1983·The New England Journal of Medicine·A J McMichaelP A Beare
Jan 1, 1981·Journal of Wildlife Diseases·C W Smitka, H F Maassab

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Citations

Jun 21, 2011·Immunological Reviews·David Proud, Richard Leigh
Apr 22, 2010·Expert Review of Respiratory Medicine·Peter Wark
Feb 22, 2001·The Journal of Experimental Medicine·A SuzukiA Yoshimura
Jun 25, 2009·The Journal of Nutrition·Nicole M J SchwerbrockMelinda A Beck
Jun 17, 2006·American Journal of Respiratory Cell and Molecular Biology·David Proud, Chung-Wai Chow
Aug 28, 2019·Current Immunology Reviews·Pamela A Kozlowski, Anna Aldovini
May 21, 2003·International Journal of Medical Microbiology : IJMM·Per Brandtzaeg
Feb 3, 2007·Journal of Theoretical Biology·Baris HanciogluGilles Clermont
Aug 21, 2021·Frontiers in Pharmacology·Alexander A Andreev-AndrievskiyVladimir G Nesterenko
Dec 29, 1998·The Journal of Allergy and Clinical Immunology·A J Polito, D Proud

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