Influenza virus infections among a sample of hospital attendees in Ragama, Sri Lanka

The Ceylon Medical Journal
K V H K K PereraJ S M Peiris

Abstract

This study was carried out to define the types of influenza viruses circulating among humans and to understand the seasonality of influenza virus activity. Such information is essential for deciding on influenza vaccination strategy and on the appropriate time for delivering influenza vaccination, if such a vaccination policy was decided to be a priority. During the period July 2003 - August 2004, 300 nasopharyngeal aspirates (NPA) were obtained from a systematic sample of patients reported to Out-patient Department, Colombo North Teaching Hospital, Ragama with < or =4 days history of acute respiratory tract infection (ARTI). The clinical signs and symptoms of the patients were prospectively recorded. Isolation of the influenza virus was carried out by inoculating in Madin Darby Canine Kidney cell line (MDCK). The isolates were identified by immunofluorescence assay and characterised by haemagglutination inhibition test. RT-PCR was carried out on all NPA samples. Genetic sequencing and phylogenetic analysis of the haemagglutinin gene of representative viruses were carried out. Twenty three influenza A and nine influenza B viruses were isolated by cell culture methods. Influenza A H3N2 Panama/2000/99-like viruses were isolated i...Continue Reading

Citations

Mar 4, 2015·The American Journal of Tropical Medicine and Hygiene·L Gayani TillekeratneChristopher W Woods
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·David ShapiroL Gayani Tillekeratne

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