Influenza virus reactivation after remission with oseltamivir treatment in a patient undergoing nonmyeloablative bone marrow transplantation

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Shinichi KobayashiKazuo Motoyoshi

Abstract

Influenza virus infection is an important cause of mortality after hematopoietic stem cell transplantation (HSCT). Although early diagnosis followed by standard therapy with oseltamivir is thought to prevent influenza complications in myeloablative bone marrow transplant recipients, the optimal duration of therapy in these patients has not yet been determined. We describe a case of influenza virus reactivation, after remission had been achieved with standard oseltamivir therapy, in a patient undergoing nonmyeloablative bone marrow transplantation (NMBMT). A rapid diagnostic test (RDT) for influenza virus detection was performed with the ESPLINE Influenza A&B-N kit, which is a rapid, readily available, and widely used approach enabling highly specific and sensitive detection, as well as monitoring, of influenza A and B viruses. However, our case shows that a very low viral load that is undetectable by this RDT can reactivate influenza during the early phase of NMBMT. Our case suggests that oseltamivir administration for influenza infection should be continued, at least until successful engraftment, to prevent virus reactivation. The patient must be frequently and carefully monitored even after the resolution of symptoms and the ...Continue Reading

References

Apr 20, 2004·Bone Marrow Transplantation·C M MachadoC S Pannuti
Sep 10, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela J PeckMichael Boeckh
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W Garrett NicholsMichael Boeckh
Nov 22, 2005·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Michimaru HaraKazuo Miyazaki
Feb 16, 2006·The Journal of Infectious Diseases·Michael G IsonFrederick G Hayden
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Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Debie VuMichael Boeckh

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