PMID: 3773053Nov 1, 1986Paper

Influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection

Journal of Virology
P D Jones, G L Ada

Abstract

An enzyme-linked immunosorbent plaque assay is described which can reliably enumerate influenza virus-specific antibody-secreting cells and exhibits specificity similar to that of the indirect enzyme-linked immunosorbent assay. The assay was used to characterize the development of specific antibody-secreting cells, principally within lung tissue, during primary murine influenza virus infection after intranasal inoculation. Cells secreting influenza virus-specific immunoglobulin M (IgM), IgG, and IgA were detected in greatest numbers in lung tissue, and the data presented indicated that the cells may have originated from specific B-cell precursors in lung tissue which are demonstratable in vitro. At 11 months after infection, cells secreting IgG and IgA were still present in lung tissue. Influenza virus-specific antibody-secreting cells were also detected in spleen tissue and blood. Antibody-secreting cells appeared earlier in spleen than in lung tissue and declined more rapidly in spleen tissue.

References

Oct 1, 1978·Infection and Immunity·C McLaren, G M Butchko
May 1, 1976·Infection and Immunity·G H Scott, J S Walker
Dec 1, 1980·Cellular Immunology·C S Reiss, J L Schulman
Feb 25, 1983·Journal of Immunological Methods·J D Sedgwick, P G Holt
Dec 16, 1983·Journal of Immunological Methods·C C CzerkinskyA Tarkowski
Aug 1, 1982·Journal of Virological Methods·E N Al-Kaissi, A Mostratos
May 1, 1980·The Journal of Infectious Diseases·G W HammondG R Noble
Nov 1, 1980·The American Review of Respiratory Disease·D E BiceR K Wolff

❮ Previous
Next ❯

Citations

May 20, 2014·Immunologic Research·Alexander W BoydenThomas J Waldschmidt
Sep 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sathit PichyangkulDavid L Saunders
Dec 1, 1993·European Journal of Immunology·A J Ramsay, M Kohonen-Corish
Dec 1, 1994·European Journal of Immunology·G FazekasE Rajnavölgyi
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hye Mee JooMark Y Sangster
Jun 15, 2005·Scandinavian Journal of Immunology·C ColecloughJ L Hurwitz
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Y SangsterP C Doherty
Sep 2, 2011·The Journal of Clinical Investigation·Amaya I WolfJan Erikson
Jul 29, 2004·Viral Immunology·Susan L SwainDavid L Woodland
Oct 28, 1997·European Journal of Immunology·C P KalbererA G Rolink
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SicardA Valujskikh
May 30, 1998·Journal of Virology·J M MonteiroG Trinchieri
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·D G RudmannD B Tumas
Jul 16, 2019·Journal of Leukocyte Biology·Rebecca Blandino, Nicole Baumgarth
Jan 9, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan H Lam, Nicole Baumgarth
Sep 1, 1994·Journal of Virology·L HylandC Coleclough
Jan 1, 1997·Journal of Virology·P G StevensonC R Bangham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.