Abstract
Pomegranates have high levels of polyphenols (PPs) and may be a rich source of compounds with antiviral activity. We evaluated the direct anti-influenza activity of three commercially available pomegranate extracts: pomegranate juice (PJ), a concentrated liquid extract (POMxl), and a 93% PP powder extract (POMxp). The acidity of PJ and POMxl solutions contributed to rapid anti-influenza activity, but this was not a factor with POMxp. Studies using POMxp showed that 5min treatment at room temperature with 800μg/ml PPs resulted in at least a 3log reduction in the titers of influenza viruses PR8 (H1N1), X31 (H3N2), and a reassortant H5N1 virus derived from a human isolate. However, the antiviral activity was less against a coronavirus and reassortant H5N1 influenza viruses derived from avian isolates. The loss of influenza infectivity was frequently accompanied by loss of hemagglutinating activity. PP treatment decreased Ab binding to viral surface molecules, suggesting some coating of particles, but this did not always correlate with loss of infectivity. Electron microscopic analysis indicated that viral inactivation by PPs was primarily a consequence of virion structural damage. Our findings demonstrate that the direct anti-infl...Continue Reading
Citations
Dec 4, 2012·Viruses·E M Abdelwhab, Hafez M Hafez
Jun 24, 2014·Journal of Dairy Science·S Weyl-FeinsteinA Shabtay
Dec 6, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hyojin Kim, Mi Sook Chung
Jul 23, 2011·Foodborne Pathogens and Disease·Xiaowei SuDoris H D'Souza
Jun 25, 2014·Scientific Reports·B Uma ReddySaumitra Das
Apr 9, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Haider Abdul-Lateef Mousa
May 20, 2016·The Journal of Veterinary Medical Science·Tugsbaatar BaatartsogtKunitoshi Imai
Nov 17, 2015·Expert Review of Anti-infective Therapy·Roodabeh BahramsoltaniNima Rezaei
Jul 26, 2018·PloS One·Urmi PatelBalázs Rada
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Amy B Howell, Doris H D'Souza
Aug 23, 2018·Frontiers in Microbiology·Anna LuganiniGiorgio Gribaudo
Dec 21, 2019·Phytotherapy Research : PTR·Marcella DenaroDomenico Trombetta
Nov 17, 2020·Frontiers in Veterinary Science·Youssef A AttiaMohamed E Abd El-Hack
Dec 29, 2020·Journal of Immunoassay & Immunochemistry·Alice GrigoreRadu Albulescu
Oct 31, 2020·Frontiers in Nutrition·Sabina Semiz, Fadila Serdarevic
Jan 27, 2021·Food Bioscience·Taha MehanySobhy El-Sohaimy
May 14, 2021·Frontiers in Pharmacology·Alfred Francis AttahChinedum Peace Babalola
May 25, 2021·Moscow University Biological Sciences Bulletin·N A KontarovN V Yuminova
Jun 15, 2021·Frontiers in Pharmacology·Cheorl-Ho Kim
Jul 27, 2021·Saudi Journal of Biological Sciences·A T M Rafiqul IslamMd Shahinozzaman
Mar 16, 2011·Journal of Agricultural and Food Chemistry·Rong-Rong HeHiroshi Kurihara
Aug 27, 2021·The Science of the Total Environment·María Fernanda Montenegro-LandívarJavier Saurina
Sep 28, 2021·Journal of Biomolecular Structure & Dynamics·Madhulekha RakshitSabyashachi Mishra